Association of low WBC counts during disease with rapid rate of HIV disease progression, independent of baseline CD4+ T-cell count, and steady-state viral load in the entire study population and in subjects categorized as seroconverters or seroprevalent
| . | All subjects . | Seroconverters . | Seroprevalent . |
|---|---|---|---|
| Average WBC count < 4000 cells/mm3 | 1.70 (1.35-2.14) | 1.80 (1.17-2.76) | 1.64 (1.24-2.17) |
| P | < .001 | .007 | < .001 |
| Baseline CD4+ T-cell count < 350 cells/mm3 | 2.50 (1.90-3.30) | 2.08 (1.20-3.59) | 2.68 (1.94-3.70) |
| P | < .001 | .009 | < .001 |
| Steady-state viral load ≥ 20000 copies/mL | 4.54 (3.43-6.01) | 4.27 (2.70-6.75) | 4.64 (3.24-6.65) |
| P | < .001 | < .001 | < .001 |
| . | All subjects . | Seroconverters . | Seroprevalent . |
|---|---|---|---|
| Average WBC count < 4000 cells/mm3 | 1.70 (1.35-2.14) | 1.80 (1.17-2.76) | 1.64 (1.24-2.17) |
| P | < .001 | .007 | < .001 |
| Baseline CD4+ T-cell count < 350 cells/mm3 | 2.50 (1.90-3.30) | 2.08 (1.20-3.59) | 2.68 (1.94-3.70) |
| P | < .001 | .009 | < .001 |
| Steady-state viral load ≥ 20000 copies/mL | 4.54 (3.43-6.01) | 4.27 (2.70-6.75) | 4.64 (3.24-6.65) |
| P | < .001 | < .001 | < .001 |
Results are from full multivariate Cox proportional hazards models showing relative hazards (95% confidence interval) for time to death and P value.