PGE analysis demonstrates enrichment of several chromosomal regions including 2 areas in which 2 of the 6 signature genes are located
| Chromosome . | Start position . | End position . | Chromosomal region . | No. of input genes in the region . | No. of genes in the region . | % enrichment . |
|---|---|---|---|---|---|---|
| 1 | 151596954 | 151789236 | q21.3 | 6 | 10 | 60.00 |
| 1 | 201403562 | 201587240 | q32.1 | 5 | 5 | 100.00 |
| 2 | 160664438 | 162639298 | q24.2 | 8 | 10 | 80.00 |
| 3 | 101566831 | 102795969 | q12.2-q12.3 | 6 | 10 | 60.00 |
| 3 | 137167257 | 137953935 | q22.2-q22.3 | 4 | 4 | 100.00 |
| 4 | 15313738 | 20229900 | p15.32-p15.31 | 8 | 16 | 50.00 |
| 4 | 77173975 | 80052363 | q21.1-q21.21 | 9 | 18 | 50.00 |
| 4 | 77173975 | 77450763 | q21.1 | 4 | 4 | 100.00 |
| 5 | 135392644 | 137503031 | q31.1-q31.2 | 7 | 14 | 50.00 |
| 8 | 6344580 | 6901669 | p23.1 | 7 | 10 | 70.00 |
| 9 | 4701155 | 5460547 | p24.1 | 6 | 10 | 60.00 |
| 11 | 59279108 | 59390594 | q12.1 | 4 | 4 | 100.00 |
| 12 | 2870294 | 6511381 | p13.33-p13.31 | 12 | 37 | 32.43 |
| 12 | 21175403 | 29378272 | p12.2-p11.22 | 16 | 55 | 29.09 |
| 12 | 32003620 | 32789750 | p11.21 | 5 | 7 | 71.43 |
| 12 | 91061030 | 97519906 | q21.33-q23.1 | 15 | 43 | 34.88 |
| 12 | 92385401 | 93377851 | q22 | 5 | 5 | 100.00 |
| 13 | 72227541 | 93857656 | q22.1-q32.1 | 12 | 30 | 40.00 |
| 19 | 56807156 | 56965572 | q13.33 | 4 | 4 | 100.00 |
| X | 55760897 | 56611026 | p11.21-p11.1 | 4 | 4 | 100.00 |
| Chromosome . | Start position . | End position . | Chromosomal region . | No. of input genes in the region . | No. of genes in the region . | % enrichment . |
|---|---|---|---|---|---|---|
| 1 | 151596954 | 151789236 | q21.3 | 6 | 10 | 60.00 |
| 1 | 201403562 | 201587240 | q32.1 | 5 | 5 | 100.00 |
| 2 | 160664438 | 162639298 | q24.2 | 8 | 10 | 80.00 |
| 3 | 101566831 | 102795969 | q12.2-q12.3 | 6 | 10 | 60.00 |
| 3 | 137167257 | 137953935 | q22.2-q22.3 | 4 | 4 | 100.00 |
| 4 | 15313738 | 20229900 | p15.32-p15.31 | 8 | 16 | 50.00 |
| 4 | 77173975 | 80052363 | q21.1-q21.21 | 9 | 18 | 50.00 |
| 4 | 77173975 | 77450763 | q21.1 | 4 | 4 | 100.00 |
| 5 | 135392644 | 137503031 | q31.1-q31.2 | 7 | 14 | 50.00 |
| 8 | 6344580 | 6901669 | p23.1 | 7 | 10 | 70.00 |
| 9 | 4701155 | 5460547 | p24.1 | 6 | 10 | 60.00 |
| 11 | 59279108 | 59390594 | q12.1 | 4 | 4 | 100.00 |
| 12 | 2870294 | 6511381 | p13.33-p13.31 | 12 | 37 | 32.43 |
| 12 | 21175403 | 29378272 | p12.2-p11.22 | 16 | 55 | 29.09 |
| 12 | 32003620 | 32789750 | p11.21 | 5 | 7 | 71.43 |
| 12 | 91061030 | 97519906 | q21.33-q23.1 | 15 | 43 | 34.88 |
| 12 | 92385401 | 93377851 | q22 | 5 | 5 | 100.00 |
| 13 | 72227541 | 93857656 | q22.1-q32.1 | 12 | 30 | 40.00 |
| 19 | 56807156 | 56965572 | q13.33 | 4 | 4 | 100.00 |
| X | 55760897 | 56611026 | p11.21-p11.1 | 4 | 4 | 100.00 |
To investigate the possibility of enrichment of differential expression on chromosome 12, we performed positional gene enrichment (PGE) analysis to detect overrepresented chromosomal regions in the CML progression-related data set. The table shows the chromosomal regions that were enriched in these analyses. Chromosome 12 is indicated in bold.
All raw P values were less than .001.