The 6-gene signature selected by BMA that discriminates chronic phase from blast crisis CML
| ID . | Gene . | Chromosome location . | Activity . | Cellular function . | Posterior probabilities, % . | Univariate (BSS/WSS) rank . |
|---|---|---|---|---|---|---|
| NM_016355 | DDX47 | 12p13.1 | RNA helicase | RNA processing, apoptosis | 20.5 | 1 |
| NM_004258 | IGSF2 | 1p13 | Signal transduction | Immune function, T-cell activation | 20.5 | 2 |
| NM_000752 | LTB4R | 14q11.2-q12 | 5-lipoxy-genase | Cell growth, apoptosis | 20.5 | 3 |
| NM_014062 | NOB1 | 16q22.1 | Unknown | Unknown | 20.5 | 13 |
| NM_005505 | SCARB1 | 12q24.31 | Cholesterol scavenger receptor | HDL and LDL metabolism | 20.5 | 69 |
| NM_005888 | SLC25A3 | 12q23 | Mitochondrial phosphate transport | ATP synthesis | 20.5 | 77 |
| ID . | Gene . | Chromosome location . | Activity . | Cellular function . | Posterior probabilities, % . | Univariate (BSS/WSS) rank . |
|---|---|---|---|---|---|---|
| NM_016355 | DDX47 | 12p13.1 | RNA helicase | RNA processing, apoptosis | 20.5 | 1 |
| NM_004258 | IGSF2 | 1p13 | Signal transduction | Immune function, T-cell activation | 20.5 | 2 |
| NM_000752 | LTB4R | 14q11.2-q12 | 5-lipoxy-genase | Cell growth, apoptosis | 20.5 | 3 |
| NM_014062 | NOB1 | 16q22.1 | Unknown | Unknown | 20.5 | 13 |
| NM_005505 | SCARB1 | 12q24.31 | Cholesterol scavenger receptor | HDL and LDL metabolism | 20.5 | 69 |
| NM_005888 | SLC25A3 | 12q23 | Mitochondrial phosphate transport | ATP synthesis | 20.5 | 77 |
The table indicates chromosomal location, function, the posterior probability of each gene in multivariate modeling, and its rank in univariate modeling (using the univariate measure of the ratio of between-group to within-group sum of squares (BSS/WSS).
BMA indicates Bayesain modeling averaging; and CML, chronic myeloid leukemia.