Genes in response to MEK1 activation
| Group/gene . | Fold change . | Definition . |
|---|---|---|
| Cytokine–cytokine receptor interaction | ||
| IL8 | 31.67 | Interleukin-8 |
| IL1B | 19.99 | Interleukin-1β |
| CCL4 | 18.89 | Chemokine (C-C motif) ligand 4 |
| CCL2 | 17.88 | Chemokine (C-C motif) ligand 2 |
| CCL7 | 9.97 | Chemokine (C-C motif) ligand 7 |
| CXCL3 | 5.73 | Chemokine (C-X-C motif) ligand 3 |
| CXCL2 | 4.2 | Chemokine (C-X-C motif) ligand 2 |
| IL1A | 2.78 | Interleukin-lα |
| CCL5 | 2.76 | Chemokine (C-C motif) ligand 5 |
| IFNGR2 | 2.61 | Interferon γ receptor 2 |
| TGFB1 | 2.25 | Transforming growth factor β 1 |
| G-CSFR | 0.42 | Granulocyte colony-stimulating factor receptor precursor |
| CD70 | 0.48 | CD70 molecule |
| NGFR | 0.5 | Nerve growth factor receptor |
| Cell cycle and apoptosis | ||
| EGR1 | 9.76 | Early growth response protein 1 |
| p21Cipl | 3.63 | Cyclin-dependent kinase inhibitor 1A |
| CCND1 | 2.96 | Cyclin D1 |
| BIRC3 | 2.85 | Baculoviral AP repeat-containing 3 |
| NFKBIA | 2.63 | NFκB inhibitor α |
| CCND3 | 2.41 | Cyclin D3 |
| MYC | 2.39 | Myc transcription factor |
| FOS | 2.15 | Fos gene family transcription factor |
| NOXA | 2.03 | Bol-2 protein family member Noxa |
| XRCC3 | 0.45 | DNA-repair protein XRCCI |
| GADD45B | 0.54 | Growth arrest and DNA-damage–inducible β |
| Group/gene . | Fold change . | Definition . |
|---|---|---|
| Cytokine–cytokine receptor interaction | ||
| IL8 | 31.67 | Interleukin-8 |
| IL1B | 19.99 | Interleukin-1β |
| CCL4 | 18.89 | Chemokine (C-C motif) ligand 4 |
| CCL2 | 17.88 | Chemokine (C-C motif) ligand 2 |
| CCL7 | 9.97 | Chemokine (C-C motif) ligand 7 |
| CXCL3 | 5.73 | Chemokine (C-X-C motif) ligand 3 |
| CXCL2 | 4.2 | Chemokine (C-X-C motif) ligand 2 |
| IL1A | 2.78 | Interleukin-lα |
| CCL5 | 2.76 | Chemokine (C-C motif) ligand 5 |
| IFNGR2 | 2.61 | Interferon γ receptor 2 |
| TGFB1 | 2.25 | Transforming growth factor β 1 |
| G-CSFR | 0.42 | Granulocyte colony-stimulating factor receptor precursor |
| CD70 | 0.48 | CD70 molecule |
| NGFR | 0.5 | Nerve growth factor receptor |
| Cell cycle and apoptosis | ||
| EGR1 | 9.76 | Early growth response protein 1 |
| p21Cipl | 3.63 | Cyclin-dependent kinase inhibitor 1A |
| CCND1 | 2.96 | Cyclin D1 |
| BIRC3 | 2.85 | Baculoviral AP repeat-containing 3 |
| NFKBIA | 2.63 | NFκB inhibitor α |
| CCND3 | 2.41 | Cyclin D3 |
| MYC | 2.39 | Myc transcription factor |
| FOS | 2.15 | Fos gene family transcription factor |
| NOXA | 2.03 | Bol-2 protein family member Noxa |
| XRCC3 | 0.45 | DNA-repair protein XRCCI |
| GADD45B | 0.54 | Growth arrest and DNA-damage–inducible β |