Response criteria in CML
| Level of response . | Definition . |
|---|---|
| Complete hematologic response | Normal complete blood count and differential |
| Minor cytogenetic response | 35%-90% Ph+ metaphases |
| Partial cytogenetic response | 1%-34% Ph+ metaphases |
| Complete cytogenetic response | 0% Ph+ metaphases |
| Major molecular response | ≥ 3-log reduction of BCR-ABL mRNA |
| Complete molecular remission | Negativity by QPCR |
| Level of response . | Definition . |
|---|---|
| Complete hematologic response | Normal complete blood count and differential |
| Minor cytogenetic response | 35%-90% Ph+ metaphases |
| Partial cytogenetic response | 1%-34% Ph+ metaphases |
| Complete cytogenetic response | 0% Ph+ metaphases |
| Major molecular response | ≥ 3-log reduction of BCR-ABL mRNA |
| Complete molecular remission | Negativity by QPCR |
Note that all cytogenetic response categories require the analysis of at least 20 metaphases.