Annual incidences of first episodes of venous thrombosis in relatives with high levels of FIX, FXI, or TAFI, or hyperhomocysteinemia
| . | Observation years . | Relatives with event . | Annual incidence, % (95% CI) . | Adjusted relative risk* (95% CI) . | P . |
|---|---|---|---|---|---|
| High FIX levels | |||||
| Absent, n=1684 | 48 702 | 124 | 0.25 (0.21-0.30)† | Reference | |
| Present, n=280 | 9751 | 24 | 0.25 (0.16-0.37) | 1.0 (0.5-1.5) | .71 |
| With normal FVIII levels, n=136 | 4400 | 3 | 0.07 (0.02-0.20) | 0.3 (0.1-0.8) | .016 |
| With high FVIII levels, n=144 | 5321 | 21 | 0.39 (0.24-0.60) | 1.5 (0.9-2.3) | .11 |
| High FXI levels | |||||
| Absent, n=2192 | 64 350 | 179 | 0.28 (0.24-0.32)‡ | Reference | |
| Present, n=148 | 4798 | 25 | 0.52 (0.33-0.77) | 2.2 (1.3-3.5) | .002 |
| With normal FVIII levels, n=62 | 1858 | 4 | 0.22 (0.06-0.55) | 0.8 (0.3-2.1) | .63 |
| With high FVIII levels, n=86 | 2940 | 21 | 0.71 (0.44-1.09) | 2.4 (1.5-3.8) | < .001 |
| High TAFI levels | |||||
| Absent, n=1824 | 53 044 | 149 | 0.28 (0.24-0.33)§ | Reference | |
| Present, n=203 | 7257 | 21 | 0.29 (0.18-0.44) | 1.0 (0.6-1.6) | .97 |
| With normal FVIII levels, n=121 | 4161 | 6 | 0.14 (0.05-0.31) | 0.5 (0.2-1.3) | .15 |
| With high FVIII levels, n=82 | 3095 | 15 | 0.49 (0.27-0.80) | 1.8 (1.0-3.6) | .073 |
| Hyperhomocysteinemia | |||||
| Absent, n=1642 | 48 075 | 127 | 0.26 (0.22-0.31)¶ | Reference | |
| Present, n=190 | 6507 | 25 | 0.38 (0.25-0.57) | 1.7 (1.0-2.9) | .05 |
| With normal FVIII levels, n=112 | 3380 | 5 | 0.14 (0.05-0.34) | 0.6 (0.2-1.4) | .20 |
| With high FVIII levels, n=78 | 3077 | 20 | 0.65 (0.40-1.00) | 2.9 (1.6-5.3) | < .001 |
| . | Observation years . | Relatives with event . | Annual incidence, % (95% CI) . | Adjusted relative risk* (95% CI) . | P . |
|---|---|---|---|---|---|
| High FIX levels | |||||
| Absent, n=1684 | 48 702 | 124 | 0.25 (0.21-0.30)† | Reference | |
| Present, n=280 | 9751 | 24 | 0.25 (0.16-0.37) | 1.0 (0.5-1.5) | .71 |
| With normal FVIII levels, n=136 | 4400 | 3 | 0.07 (0.02-0.20) | 0.3 (0.1-0.8) | .016 |
| With high FVIII levels, n=144 | 5321 | 21 | 0.39 (0.24-0.60) | 1.5 (0.9-2.3) | .11 |
| High FXI levels | |||||
| Absent, n=2192 | 64 350 | 179 | 0.28 (0.24-0.32)‡ | Reference | |
| Present, n=148 | 4798 | 25 | 0.52 (0.33-0.77) | 2.2 (1.3-3.5) | .002 |
| With normal FVIII levels, n=62 | 1858 | 4 | 0.22 (0.06-0.55) | 0.8 (0.3-2.1) | .63 |
| With high FVIII levels, n=86 | 2940 | 21 | 0.71 (0.44-1.09) | 2.4 (1.5-3.8) | < .001 |
| High TAFI levels | |||||
| Absent, n=1824 | 53 044 | 149 | 0.28 (0.24-0.33)§ | Reference | |
| Present, n=203 | 7257 | 21 | 0.29 (0.18-0.44) | 1.0 (0.6-1.6) | .97 |
| With normal FVIII levels, n=121 | 4161 | 6 | 0.14 (0.05-0.31) | 0.5 (0.2-1.3) | .15 |
| With high FVIII levels, n=82 | 3095 | 15 | 0.49 (0.27-0.80) | 1.8 (1.0-3.6) | .073 |
| Hyperhomocysteinemia | |||||
| Absent, n=1642 | 48 075 | 127 | 0.26 (0.22-0.31)¶ | Reference | |
| Present, n=190 | 6507 | 25 | 0.38 (0.25-0.57) | 1.7 (1.0-2.9) | .05 |
| With normal FVIII levels, n=112 | 3380 | 5 | 0.14 (0.05-0.34) | 0.6 (0.2-1.4) | .20 |
| With high FVIII levels, n=78 | 3077 | 20 | 0.65 (0.40-1.00) | 2.9 (1.6-5.3) | < .001 |
Numbers of relatives tested for levels of FIX, FXI, TAFI, and homocysteine were 1964, 2340, 2027, and 1832, respectively.
Adjusted for age, sex, and clustering of thrombophilic defects in families.
Annual incidence in relatives with normal FIX and FVIII levels was 0.17% (95% CI, 0.13-0.22).
Annual incidence in relatives with normal FXI and FVIII levels was 0.18% (95% CI, 0.15-0.23).
Annual incidence in relatives with normal TAFI and FVIII levels was 0.18% (95% CI, 0.14-0.23).
Annual incidence in relatives with normal homocysteine and FVIII levels was 0.19% (95% CI, 0.15-0.24).