General characteristics of patients, N = 226
| Characteristics . | N . | Sex, M/F . | Age, average y ± SD . | Blast, % . | Mean IPSS . | Cytogenetics, normal/abnormal . |
|---|---|---|---|---|---|---|
| Patients | 184 | |||||
| AML | 102 | |||||
| Primary AML | 56 | 23/33 | 54 ± 15 | 43.0 | 29/25 | |
| Secondary AML | 46 | 26/20 | 68 ± 11 | 43.0 | 11/29 | |
| MDS advanced | 28 | |||||
| RAEB1/2 | 28 | 18/10 | 63 ± 16 | 10.6 | 11/16 | |
| Low-risk MDS | 32 | |||||
| RA/RCMD | 19 | 11/8 | 65 ± 13 | 1.7 | 0.63* | 9/10 |
| RARS/RCMD-RS | 6 | 5/1 | 77 ± 3 | 1.3 | 0.21 | 5/1 |
| 5q syndrome | 3 | 0/3 | 55 ± 31 | 0.3 | 0.17 | 0/3 |
| MDS-U | 4 | 2/2 | 74 ± 8 | 2.0 | 0.75* | 1/2 |
| MDS/MPD | 22 | |||||
| MDS/MPD-U | 3 | 2/1 | 72 ± 6 | 5.0 | 0.83 | 1/2 |
| RARS-T | 5 | 3/2 | 73 ± 7 | 1.0 | 0 | 5/0 |
| CMML1/2 | 14 | 5/9 | 67 ± 10 | 18.3 | 11/3 | |
| Control | 42 | 20/22 | 43 ± 29 |
| Characteristics . | N . | Sex, M/F . | Age, average y ± SD . | Blast, % . | Mean IPSS . | Cytogenetics, normal/abnormal . |
|---|---|---|---|---|---|---|
| Patients | 184 | |||||
| AML | 102 | |||||
| Primary AML | 56 | 23/33 | 54 ± 15 | 43.0 | 29/25 | |
| Secondary AML | 46 | 26/20 | 68 ± 11 | 43.0 | 11/29 | |
| MDS advanced | 28 | |||||
| RAEB1/2 | 28 | 18/10 | 63 ± 16 | 10.6 | 11/16 | |
| Low-risk MDS | 32 | |||||
| RA/RCMD | 19 | 11/8 | 65 ± 13 | 1.7 | 0.63* | 9/10 |
| RARS/RCMD-RS | 6 | 5/1 | 77 ± 3 | 1.3 | 0.21 | 5/1 |
| 5q syndrome | 3 | 0/3 | 55 ± 31 | 0.3 | 0.17 | 0/3 |
| MDS-U | 4 | 2/2 | 74 ± 8 | 2.0 | 0.75* | 1/2 |
| MDS/MPD | 22 | |||||
| MDS/MPD-U | 3 | 2/1 | 72 ± 6 | 5.0 | 0.83 | 1/2 |
| RARS-T | 5 | 3/2 | 73 ± 7 | 1.0 | 0 | 5/0 |
| CMML1/2 | 14 | 5/9 | 67 ± 10 | 18.3 | 11/3 | |
| Control | 42 | 20/22 | 43 ± 29 |
In some analyses, primary AML and secondary AML were analyzed together with RAEB1/2. MDS low risk was analyzed together with MDS/MPD-U and RARS-T.
RA indicates refractory anemia; RCMD, refractory cytopenia with multilineage dysplasia; RARS, refractory anemia with ringed sideroblasts; RCMD-RS, refractory cytopenia with multilineage dysplasia and ringed sideroblasts; MDS-U, myelodysplasia unclassifiable; MPD-U, myeloproliferative disorders unclassifiable; RARS-T, refractory anemia with ringed sideroblasts associated with marked thrombocytosis; and CMML, chronic myelomonocytic leukemia.
Contains patients who cannot be analyzed for IPSS.