Comparison of the APC populations in the human axillary lymph nodes with the APC in human skin
| APC population . | CD1a . | CD1b . | CD14 . | CD68 . | CD206 . | CD207 . | CD208 . | CD209 . | BDCA2 . | References . |
|---|---|---|---|---|---|---|---|---|---|---|
| Lymph node APC populations | ||||||||||
| Migratory CD1a+CD207+ Langerhans cells | ++ | +/− | − | − | − | ++ | +/− | − | − | |
| Migratory CD1a+CD207− dermal APCs | ++ | +/− | − | − | − | − | +/− | − | − | |
| CD208+ interdigitating APCs | − | +/− | − | − | − | − | ++ | − | − | |
| CD209+ APCs | ||||||||||
| In diffuse T-lymphocyte zones of paracortex | − | − | +/− | ++ | +/− | − | − | + | − | |
| In medullary cords | − | − | ++ | ++ | ++ | − | − | ++ | − | |
| Subcapsular and trabecular | − | − | ++ | ++ | +/− | − | − | ++ | − | |
| Plasmacytoid APCs | − | − | − | − | − | − | − | − | ++ | |
| Cutaneous APC populations | ||||||||||
| Epidermal Langerhans cells | ++ | − | − | − | − | ++ | − | − | − | 12, 24 |
| Dermal CD207+ APCs | ++ | ++ | − | − | − | ++ | ++ | − | − | 26 |
| CD1a+ dermal APCs | ++ | ++ | − | − | − | − | − | − | − | 12, 26 |
| CD14+ dermal APCs | − | + | ++ | ++ | ++ | − | − | ++ | − | 12, 26 |
| APC population . | CD1a . | CD1b . | CD14 . | CD68 . | CD206 . | CD207 . | CD208 . | CD209 . | BDCA2 . | References . |
|---|---|---|---|---|---|---|---|---|---|---|
| Lymph node APC populations | ||||||||||
| Migratory CD1a+CD207+ Langerhans cells | ++ | +/− | − | − | − | ++ | +/− | − | − | |
| Migratory CD1a+CD207− dermal APCs | ++ | +/− | − | − | − | − | +/− | − | − | |
| CD208+ interdigitating APCs | − | +/− | − | − | − | − | ++ | − | − | |
| CD209+ APCs | ||||||||||
| In diffuse T-lymphocyte zones of paracortex | − | − | +/− | ++ | +/− | − | − | + | − | |
| In medullary cords | − | − | ++ | ++ | ++ | − | − | ++ | − | |
| Subcapsular and trabecular | − | − | ++ | ++ | +/− | − | − | ++ | − | |
| Plasmacytoid APCs | − | − | − | − | − | − | − | − | ++ | |
| Cutaneous APC populations | ||||||||||
| Epidermal Langerhans cells | ++ | − | − | − | − | ++ | − | − | − | 12, 24 |
| Dermal CD207+ APCs | ++ | ++ | − | − | − | ++ | ++ | − | − | 26 |
| CD1a+ dermal APCs | ++ | ++ | − | − | − | − | − | − | − | 12, 26 |
| CD14+ dermal APCs | − | + | ++ | ++ | ++ | − | − | ++ | − | 12, 26 |
++ indicates strong expression on all cells; +, weak expression on all cells; −, no expression on any cells; and +/−, expressed by some cells but not others.