Spontaneous bleeding episodes in the hemophilia-treated dogs and untreated HA and HB controls recorded concurrently with this study
| Dog . | Vector, vector genomes/kg . | Spontaneous bleeds, observed/expected . | Months observed . | Untreated HA, bleeds/observation period (mo) . | Untreated HB, bleeds/observation period (mo) . |
|---|---|---|---|---|---|
| HB-1-J10 | 2.06E13 | 0/15* | 34 | Dog 1 (8/24) | Dog 1 (4/12) |
| HA-1-J55 | 6.25E13 | 0/8 | 18 | Dog 2 (4/12) | Dog 2 (9/24) |
| HA-2-J57 | 1.25E14 | 0/7 | 15 | Dog 3 (8/24) | |
| HA-3-E66 | 1.25E14 | 0/6 | 12 | ||
| Cumulative spontaneous bleeds | 12 in 36 mo | 21 in 60 mo | |||
| HB | 0 in 34 mo | ||||
| HA | 0 in 45 mo | ||||
| Expected spontaneous bleeds | |||||
| HB | 15 in 34 mo | ||||
| HA | 21 in 45 mo | ||||
| Dog . | Vector, vector genomes/kg . | Spontaneous bleeds, observed/expected . | Months observed . | Untreated HA, bleeds/observation period (mo) . | Untreated HB, bleeds/observation period (mo) . |
|---|---|---|---|---|---|
| HB-1-J10 | 2.06E13 | 0/15* | 34 | Dog 1 (8/24) | Dog 1 (4/12) |
| HA-1-J55 | 6.25E13 | 0/8 | 18 | Dog 2 (4/12) | Dog 2 (9/24) |
| HA-2-J57 | 1.25E14 | 0/7 | 15 | Dog 3 (8/24) | |
| HA-3-E66 | 1.25E14 | 0/6 | 12 | ||
| Cumulative spontaneous bleeds | 12 in 36 mo | 21 in 60 mo | |||
| HB | 0 in 34 mo | ||||
| HA | 0 in 45 mo | ||||
| Expected spontaneous bleeds | |||||
| HB | 15 in 34 mo | ||||
| HA | 21 in 45 mo | ||||
The HB (male) dog exhibited 3 nonspontaneous bleeding episodes within the first 8 months of observation.