Genes involved in the “DNA damage” functional category, deregulated by Zalypsis in MM1S and OPM-1 cells
| Probe set . | Gene symbol . | MM1S FC . | OPM1 FC . | Description . |
|---|---|---|---|---|
| 212986_s_at | TLK2 | −2.65 | Tousled-like kinase 2 | |
| 203725_at | GADD45A | 2.58 | Growth arrest and DNA-damage-inducible, alpha | |
| 222879_s_at | POLH | 3.34 | Polymerase (DNA directed), eta | |
| 203409_at | DDB2 | 3.81 | Damage-specific DNA binding protein 2, 48kDa | |
| 236535_at | SMC6 | −16.06 | SMC6 structural maintenance of chromosomes 6-like 1 (yeast) | |
| 209849_s_at | RAD51C | −5.26 | RAD51 homolog C (S. cerevisiae) | |
| 209902_at | ATR | −4.74 | Ataxia telangiectasia and Rad3 related | |
| 228535_at | RAD1 | −4.69 | RAD1 homolog (S. pombe) | |
| 204146_at | RAD51AP1 | −4.59 | RAD51 associated protein 1 | |
| 210416_s_at | CHEK2 | −3.99 | CHK2 checkpoint homolog (S. pombe) | |
| 201589_at | SMC1A | −3.41 | SMC1 structural maintenance of chromosomes 1-like 1 (yeast) | |
| 201223_s_at | RAD23B | −2.95 | RAD23 homolog B (S. cerevisiae) | |
| 218527_at | APTX | −2.9 | Aprataxin | |
| 214426_x_at | CHAF1A | −2.65 | Chromatin assembly factor 1, subunit A (p150) | |
| 205024_s_at | RAD51 | −2.61 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | |
| 219510_at | POLQ | −2.59 | Polymerase (DNA directed), theta | |
| 223261_at | POLK | −2.48 | Polymerase (DNA directed) kappa | |
| 201746_at | TP53 | 2.42 | Tumor protein p53 (Li-Fraumeni syndrome) | |
| 210886_x_at | TP53AP1 | 3.54 | TP53-activated protein 1 | |
| 205072_s_at | XRCC4 | −9.32 | −19.94 | X-ray repair complementing defective repair in cells 4 |
| 208393_s_at | RAD50 | −3.93 | −7.95 | RAD50 homolog (S cerevisiae) |
| 208643_s_at | XRCC5 | −2.5 | −14.01 | X-ray repair complementing defective repair in cells 5 |
| 235609_at | BRIP1 | −2.42 | −7.32 | BRCA1-interacting protein C-terminal helicase 1 |
| 239635_at | TMEM137 | 2.52 | 3.81 | RNA-binding motif protein 14 |
| 205875_s_at | TREX1 | 2.72 | 4.21 | Three prime repair exonuclease 1 |
| 238736_at | REV3L | 4.18 | 3.5 | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) |
| Probe set . | Gene symbol . | MM1S FC . | OPM1 FC . | Description . |
|---|---|---|---|---|
| 212986_s_at | TLK2 | −2.65 | Tousled-like kinase 2 | |
| 203725_at | GADD45A | 2.58 | Growth arrest and DNA-damage-inducible, alpha | |
| 222879_s_at | POLH | 3.34 | Polymerase (DNA directed), eta | |
| 203409_at | DDB2 | 3.81 | Damage-specific DNA binding protein 2, 48kDa | |
| 236535_at | SMC6 | −16.06 | SMC6 structural maintenance of chromosomes 6-like 1 (yeast) | |
| 209849_s_at | RAD51C | −5.26 | RAD51 homolog C (S. cerevisiae) | |
| 209902_at | ATR | −4.74 | Ataxia telangiectasia and Rad3 related | |
| 228535_at | RAD1 | −4.69 | RAD1 homolog (S. pombe) | |
| 204146_at | RAD51AP1 | −4.59 | RAD51 associated protein 1 | |
| 210416_s_at | CHEK2 | −3.99 | CHK2 checkpoint homolog (S. pombe) | |
| 201589_at | SMC1A | −3.41 | SMC1 structural maintenance of chromosomes 1-like 1 (yeast) | |
| 201223_s_at | RAD23B | −2.95 | RAD23 homolog B (S. cerevisiae) | |
| 218527_at | APTX | −2.9 | Aprataxin | |
| 214426_x_at | CHAF1A | −2.65 | Chromatin assembly factor 1, subunit A (p150) | |
| 205024_s_at | RAD51 | −2.61 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | |
| 219510_at | POLQ | −2.59 | Polymerase (DNA directed), theta | |
| 223261_at | POLK | −2.48 | Polymerase (DNA directed) kappa | |
| 201746_at | TP53 | 2.42 | Tumor protein p53 (Li-Fraumeni syndrome) | |
| 210886_x_at | TP53AP1 | 3.54 | TP53-activated protein 1 | |
| 205072_s_at | XRCC4 | −9.32 | −19.94 | X-ray repair complementing defective repair in cells 4 |
| 208393_s_at | RAD50 | −3.93 | −7.95 | RAD50 homolog (S cerevisiae) |
| 208643_s_at | XRCC5 | −2.5 | −14.01 | X-ray repair complementing defective repair in cells 5 |
| 235609_at | BRIP1 | −2.42 | −7.32 | BRCA1-interacting protein C-terminal helicase 1 |
| 239635_at | TMEM137 | 2.52 | 3.81 | RNA-binding motif protein 14 |
| 205875_s_at | TREX1 | 2.72 | 4.21 | Three prime repair exonuclease 1 |
| 238736_at | REV3L | 4.18 | 3.5 | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) |