Laboratory and clinical characteristics of MPLW515L and W5151K mutated patients compared with MPL wild-type patients, who were categorized according to their JAK2V617F mutational status
| . | MPL . | JAK2 . | P value . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| W515L (A) . | W515K (B) . | wild-type (C) . | V617F (D) . | (A) vs (B) . | (A) vs (C) . | (A) vs (D) . | (B) vs (C) . | (B) vs (D) . | |
| Number of patients | 18 | 12 | 418 | 546 | — | — | — | — | — |
| Male, no (%) | 7 (38.8) | 2 (16.6) | 144 (34) | 170 (31) | .2 | .7 | .8 | .5 | .5 |
| Median age, y* | 67 (31-84) | 48 (22-66) | 50 (8-87) | 56 (15-97) | .004 | .01 | .89 | .6 | .1 |
| MPL mutant allele burden, %† | 37 ± 23 | 53 ± 26 | — | — | .09 | — | — | — | — |
| JAK2V617F mutated, no (%) | 3 (17%) | 5 (42%) | — | — | .2 | — | — | — | — |
| JAK2V617F allele burden, %† | 13 ± 14 | 10 ± 15 | — | 25 ± 13 | .9 | — | .02 | — | .01 |
| White blood cell count, × 109/L† | 8.3 ± 2.9 | 9.5 ± 3.3 | 8.5 ± 2.1 | 9.5 ± 3.1 | .5 | .6 | .1 | .4 | .9 |
| Hemoglobin, g/L† | 129 ± 13 | 142 ± 90 | 135 ± 22 | 142 ± 21 | .003 | .01 | <.001 | .07 | .6 |
| Platelet count, × 109/L† | 882 ± 358 | 1060 ± 270 | 935 ± 315 | 791 ± 211 | .01 | .2 | .1 | .07 | <.001 |
| LDH, U/L† | 493 ± 249 | 431 ± 102 | 336 ± 128 | 338 ± 116 | .8 | .1 | .01 | .06 | .02 |
| Serum ferritin, μg/L† | 140 ± 106 | 80 ± 34 | 82 ± 85 | 93 ± 96 | .6 | .07 | .23 | .5 | .6 |
| . | MPL . | JAK2 . | P value . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| W515L (A) . | W515K (B) . | wild-type (C) . | V617F (D) . | (A) vs (B) . | (A) vs (C) . | (A) vs (D) . | (B) vs (C) . | (B) vs (D) . | |
| Number of patients | 18 | 12 | 418 | 546 | — | — | — | — | — |
| Male, no (%) | 7 (38.8) | 2 (16.6) | 144 (34) | 170 (31) | .2 | .7 | .8 | .5 | .5 |
| Median age, y* | 67 (31-84) | 48 (22-66) | 50 (8-87) | 56 (15-97) | .004 | .01 | .89 | .6 | .1 |
| MPL mutant allele burden, %† | 37 ± 23 | 53 ± 26 | — | — | .09 | — | — | — | — |
| JAK2V617F mutated, no (%) | 3 (17%) | 5 (42%) | — | — | .2 | — | — | — | — |
| JAK2V617F allele burden, %† | 13 ± 14 | 10 ± 15 | — | 25 ± 13 | .9 | — | .02 | — | .01 |
| White blood cell count, × 109/L† | 8.3 ± 2.9 | 9.5 ± 3.3 | 8.5 ± 2.1 | 9.5 ± 3.1 | .5 | .6 | .1 | .4 | .9 |
| Hemoglobin, g/L† | 129 ± 13 | 142 ± 90 | 135 ± 22 | 142 ± 21 | .003 | .01 | <.001 | .07 | .6 |
| Platelet count, × 109/L† | 882 ± 358 | 1060 ± 270 | 935 ± 315 | 791 ± 211 | .01 | .2 | .1 | .07 | <.001 |
| LDH, U/L† | 493 ± 249 | 431 ± 102 | 336 ± 128 | 338 ± 116 | .8 | .1 | .01 | .06 | .02 |
| Serum ferritin, μg/L† | 140 ± 106 | 80 ± 34 | 82 ± 85 | 93 ± 96 | .6 | .07 | .23 | .5 | .6 |