Multivariable analysis for disease-free survival
| Variable* . | P . | Hazard ratio (95% CI) . |
|---|---|---|
| FLT3-TKD vs FLT3-WT | .02 | 2.3 (1.1-4.7) |
| NPM1-mutated vs NPM1-WT | .02 | 0.5 (0.3-0.9) |
| Percent BM blasts | .17 | 1.1 (1.0-1.3)† |
| Variable* . | P . | Hazard ratio (95% CI) . |
|---|---|---|
| FLT3-TKD vs FLT3-WT | .02 | 2.3 (1.1-4.7) |
| NPM1-mutated vs NPM1-WT | .02 | 0.5 (0.3-0.9) |
| Percent BM blasts | .17 | 1.1 (1.0-1.3)† |
Hazard ratios greater than (less than) 1 indicate an increased (decreased) risk of relapse for higher values of continuous variables and the first category listed for dichotomous variables.
FLT3-TKD indicates tyrosine kinase domain mutation of the FLT3 gene; FLT3-WT, wild-type FLT3; BM, bone marrow.
Variables considered for model inclusion were age, sex, race, hemoglobin, platelet and WBC count, percentage of blood and BM blasts, extramedullary involvement, MLL-PTD, and NPM1 mutation status. Only NPM1 mutation status, percentage of BM blasts, and WBC count had a P < .20 in univariable analyses and were fit with FLT3-TKD in a full model. The final model is shown.
Hazard ratio provided for a 10% increase in BM blasts.