Gene Set Enrichment Analysis of leukemic LGLs compared with normal activated PBMCs (EDG Pathway)
| Gene symbol . | Description . | Running ES . | Core enrichment . |
|---|---|---|---|
| NGFR | Nerve growth factor receptor (TNFR superfamily, member 16) | 0.07697 | Yes |
| NTF3 | Neurotrophin 3 | 0.156094 | Yes |
| PLCB1 | Phospholipase C, beta 1 (phosphoinositide-specific) | 0.200503 | Yes |
| SKIP | Sphingosine kinase interacting protein | 0.25146 | Yes |
| PDGFA | Platelet-derived growth factor alpha polypeptide | 0.286498 | Yes |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 0.330995 | Yes |
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.363285 | Yes |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.413042 | Yes |
| EDG8 | Endothelial differentiation, sphingolipid G-protein–coupled receptor, 8 | 0.420597 | Yes |
| SMPD2 | Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 0.431073 | Yes |
| SPHK1 | Sphingosine kinase 1 | 0.461875 | Yes |
| SMPD1 | Sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) | 0.489334 | Yes |
| SRC | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.447001 | No |
| ITGB3 | Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.458506 | No |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | 0.465336 | No |
| PRKCB1 | Protein kinase C, beta 1 | 0.401243 | No |
| ITGAV | Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 0.417259 | No |
| ADCY1 | Adenylate cyclase 1 (brain) | 0.340516 | No |
| MAPK1 | Mitogen-activated protein kinase 1 | 0.269841 | No |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP-binding protein Rac1) | 0.252438 | No |
| PIK3CA | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.23775 | No |
| VEGF | Vascular endothelial growth factor | 0.226998 | No |
| GNAI1 | Guanine nucleotide–binding protein (G-protein), alpha-inhibiting activity polypeptide 1 | 0.218014 | No |
| GNGT1 | Guanine nucleotide–binding protein (G-protein), gamma-transducing activity polypeptide 1 | 0.18675 | No |
| PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | 0.179572 | No |
| EDG1 | Endothelial differentiation, sphingolipid G-protein–coupled receptor, 1 | 0.169923 | No |
| GNB1 | Guanine nucleotide binding protein (G-protein), beta polypeptide 1 | 0.116622 | No |
| PRKCA | Protein kinase C, alpha | −0.02572 | No |
| MAPK3 | Mitogen-activated protein kinase 3 | 0.01941 | No |
| Gene symbol . | Description . | Running ES . | Core enrichment . |
|---|---|---|---|
| NGFR | Nerve growth factor receptor (TNFR superfamily, member 16) | 0.07697 | Yes |
| NTF3 | Neurotrophin 3 | 0.156094 | Yes |
| PLCB1 | Phospholipase C, beta 1 (phosphoinositide-specific) | 0.200503 | Yes |
| SKIP | Sphingosine kinase interacting protein | 0.25146 | Yes |
| PDGFA | Platelet-derived growth factor alpha polypeptide | 0.286498 | Yes |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 0.330995 | Yes |
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.363285 | Yes |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.413042 | Yes |
| EDG8 | Endothelial differentiation, sphingolipid G-protein–coupled receptor, 8 | 0.420597 | Yes |
| SMPD2 | Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 0.431073 | Yes |
| SPHK1 | Sphingosine kinase 1 | 0.461875 | Yes |
| SMPD1 | Sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) | 0.489334 | Yes |
| SRC | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.447001 | No |
| ITGB3 | Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.458506 | No |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | 0.465336 | No |
| PRKCB1 | Protein kinase C, beta 1 | 0.401243 | No |
| ITGAV | Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 0.417259 | No |
| ADCY1 | Adenylate cyclase 1 (brain) | 0.340516 | No |
| MAPK1 | Mitogen-activated protein kinase 1 | 0.269841 | No |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP-binding protein Rac1) | 0.252438 | No |
| PIK3CA | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.23775 | No |
| VEGF | Vascular endothelial growth factor | 0.226998 | No |
| GNAI1 | Guanine nucleotide–binding protein (G-protein), alpha-inhibiting activity polypeptide 1 | 0.218014 | No |
| GNGT1 | Guanine nucleotide–binding protein (G-protein), gamma-transducing activity polypeptide 1 | 0.18675 | No |
| PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | 0.179572 | No |
| EDG1 | Endothelial differentiation, sphingolipid G-protein–coupled receptor, 1 | 0.169923 | No |
| GNB1 | Guanine nucleotide binding protein (G-protein), beta polypeptide 1 | 0.116622 | No |
| PRKCA | Protein kinase C, alpha | −0.02572 | No |
| MAPK3 | Mitogen-activated protein kinase 3 | 0.01941 | No |