Summary of genes expressed in E11.5 3PPs
| Gene . | Synonym . | Category . | Pharyngeal functions . | References . |
|---|---|---|---|---|
| Pax1 | Paired box 1 | Transcription factor | Pharyngeal development | 15,16 |
| Gcm2 | Glial cells missing homolog 2 | Transcription factor | Parathyroid development | 19,42 |
| Casr | Calcium-sensing receptor | Receptor | Parathyroid function | 43 |
| PTH | Parathyroid hormone | Hormone | Parathyroid function | 44 |
| CCL21 | CC chemokine ligand 21 | Chemokine | Parathyroid/thymus function | 23,45 |
| IL7 | Interleukin 7 | Cytokine | Thymus function | 46 |
| MafB | Transcription factor | Unknown | ||
| Irs4 | Insulin receptor substrate 4 | Receptor signaling | Unknown | |
| Pla2g7 | PAF acetylhydrolase | Phospholipase | Unknown | |
| Nedd4 | Ubiquitin ligase | Unknown | ||
| Agpt2 | Angiopoietin 2 | Angiogenesis | Unknown | |
| Spink8 | Tof2 | Peptidase inhibitor | Unknown |
| Gene . | Synonym . | Category . | Pharyngeal functions . | References . |
|---|---|---|---|---|
| Pax1 | Paired box 1 | Transcription factor | Pharyngeal development | 15,16 |
| Gcm2 | Glial cells missing homolog 2 | Transcription factor | Parathyroid development | 19,42 |
| Casr | Calcium-sensing receptor | Receptor | Parathyroid function | 43 |
| PTH | Parathyroid hormone | Hormone | Parathyroid function | 44 |
| CCL21 | CC chemokine ligand 21 | Chemokine | Parathyroid/thymus function | 23,45 |
| IL7 | Interleukin 7 | Cytokine | Thymus function | 46 |
| MafB | Transcription factor | Unknown | ||
| Irs4 | Insulin receptor substrate 4 | Receptor signaling | Unknown | |
| Pla2g7 | PAF acetylhydrolase | Phospholipase | Unknown | |
| Nedd4 | Ubiquitin ligase | Unknown | ||
| Agpt2 | Angiopoietin 2 | Angiogenesis | Unknown | |
| Spink8 | Tof2 | Peptidase inhibitor | Unknown |
The 12 genes selectively expressed in E11.5 3PPs are divided into two groups. The 6 genes in the top group are known for their roles in the development or function of parathyroid glands or thymus. The involvement in pharyngeal region of the 6 genes in the bottom group has not been identified.