Table 1 IC 50 values of the p110... | American Society of Hematology

Table 1

IC₅₀ values of the p110 isoform-specific PI3K inhibitors with pure p110 enzymes

Inhibitor	Abbreviation	IC₅₀, μM
Inhibitor	Abbreviation	p110α	p110β	p110γ	p110δ
PIK-90	1	0.011	0.35	0.018	0.058
PIK-93	2	0.039	0.59	0.016	0.12
PI-103	3	0.008	0.088	0.015	0.048
TGX-221	4	5.0	0.005	> 10.0	0.1
SW18	5	6.7	2.4	0.038	0.005
SW30	6	85	0.74	1.3	0.007
AS605240	7	0.06	0.27	0.008	0.3

Inhibitor	Abbreviation	IC₅₀, μM
Inhibitor	Abbreviation	p110α	p110β	p110γ	p110δ
PIK-90	1	0.011	0.35	0.018	0.058
PIK-93	2	0.039	0.59	0.016	0.12
PI-103	3	0.008	0.088	0.015	0.048
TGX-221	4	5.0	0.005	> 10.0	0.1
SW18	5	6.7	2.4	0.038	0.005
SW30	6	85	0.74	1.3	0.007
AS605240	7	0.06	0.27	0.008	0.3

The IC₅₀ values using intact cells are 10 to 100 times higher.³⁰