Tyrosine phosphorylated peptides that changed their phosphorylation status while ALK was inhibited by shRNA or a pharmacologic inhibitor
Gene symbol . | Peptide . | PTyr site . | Protein . | *Average H:L . | NCBI access no. . | shALK . | ALK inhibitor . |
---|---|---|---|---|---|---|---|
Peptides that decrease when ALK is reduced | |||||||
Kinases | |||||||
ALK | R.TSTIMTDYNPNY*CFAGK | 1096 | Anaplastic lymphoma kinase | 1:6.20 | NP_004295 | 1 | 1 |
ALK | R.NKPTSLWNPTY*GSWFTEKPTK | 1507 | Anaplastic lymphoma kinase | 1:3.72 | NP_004295 | 2 | 1 |
CDC2 | K.IEKIGEGTY*GVVYK | 15 | Cell division cycle 2 protein | 1:2.7 | NP_203698 | 2 | 1 |
CDK2 | K.VEKIGEGTY*GVVYK | 15 | Cyclin dependent kinase 2 | >1:6 | NP_001789 | 2 | 1 |
ERK1/MAPK3 | R.IADPEHDHTGFLTEY*VATR | 187 | Mitogen-activated protein kinase 3 | 1:2.07 | NP_002737 | Not found | 2 |
p38/MAPK14 | R.HTDDEMTGY*VATR | 182 | Mitogen-activated protein kinase 14 | 1:3.22 | NP_620581 | 2 | 1 |
Adaptors | |||||||
HGS | R.VCEPCY*EQLNR | 216 | HGF regulated tyrosine kinase substrate | >1:4 | NP_004703 | Not found | 1 |
PAG | K.SGQSLTVPESTY*TSIQGDPQR | 341 | Phosphoprotein associated with glycosphingo | 1.47:1 | NP_060910 | Not found | 3 |
PARD3 | R.DVTIGGSAPIY*VK | 489 | par-3 partitioning defective 3 homolog | >1:4 | NP_062565 | Not found | 2 |
Cytoskeletal proteins | |||||||
ACTB | R.KDLY*ANTVLSGGTTMYPGIADR.M | 294 | Actin, β | 1:5.71 | NP_001092 | 1 | Not found |
ACTB | K.EKLCY*VALDFEQEMATAASSSSLEK.S | 218 | Actin, β | >1:3 | NP_001092 | 1 | 1 |
CORO1C | R.YFEITDESPY*VHYLNTFSSK.E | 301 | Coronin, actin binding protein, 1C | 1:2.47 | NP_055140 | 3 | 1 |
VASP | R.VQIY*HNPTANSFR.V | 39 | Vasodilator-stimulated phosphoprotein | >1:9 | NP_003361 | 1 | 1 |
VIM | R.FANY*IDKVR.F | 117 | Vimentin | >1:6 | NP_003371 | 2 | 1 |
Chaperones | |||||||
HSP90AB1 | K.SIY*YITGESK.E | 484 | Heat shock protein 90kDa α | 1:2.74 | NP_031381 | 4 | 1 |
HSPA2 | R.TTPSY*VAFTDTER.L | 43 | Heat shock 70kDa protein 2 | >1:2 | NP_068814 | Not found | 1 |
HSPA4 | K.LKKEDIY*AVEIVGGATR.I | 336 | Heat shock 70kDa protein 4 | 1:2.66 | NP_002145 | 2 | 1 |
TRAP1 | R.NIY*YLCAPNR.H | 498 | TNF receptor-associated protein 1 | 1:2.9 | NP_057376 | 1 | 1 |
Cytokines | |||||||
PBEF | K.YLLETSGNLDGLEY*KLHDFGYR.G | 188 | Pre-B-cell colony enhancing factor 1 | 1:2.04 | NP_005737 | 1 | 1 |
Energy metabolism | |||||||
RASA1 | K.HFTNPY*CNIYLNSVQVAK.T | 615 | RAS p21 protein activator 1 | 1:3.25 | NP_072179 | ||
Metabolic enzymes | |||||||
ACLY | R.TTDGVY*EGVAIGGDRYPGSTFMDHVLR.Y | 682 | ATP cytrate lyase | 1:4.27 | NP_001087 | 1 | 1 |
ACP1 | K.QLIIEDPYYGNDSDFETVY*QQCVR.C | 143 | Acidic phosphatase 1 | 1:5.2 | NP_004291 | 2 | 1 |
ATIC | VVACNLyPFVK | 104 | AICAR formyltransferase/IMP Chase | 1:3.70 | NP_004035 | 1 | 1 |
ELP3 | R.NLHDALSGHTSNNIY*EAVK.Y | 202 | Elongation protein 3 | 1:5.57 | NP_060561 | 2 | 1 |
ENO1 | K.SFIKDY*PVVSIEDPFDQDDWGAWQK.F | 287 | Enolase 1 | 1:2.91 | NP_001419 | 1 | 1 |
GBE1 | R.EGDNVNY*DWIHWDPEHSYEFK.H | 173 | Glucan (1,4-α-), branching enzyme 1 | 1:1.86 | NP_000149 | 3 | 1 |
LDHA | K.QVVESAY*EVIK.L | 239 | Lactate dehydrogenase A | 1:3.03 | NP_005557 | 2 | 1 |
LDHB | K.MVVESAY*EVIK.L | 240 | Lactate dehydrogenase B | 1:4.00 | NP_002291 | 1 | 1 |
NIT2 | K.TLSPGDSFSTFDTPY*CR.V | 145 | Nitrilase family, member 2 | 1:4.14 | NP_064587 | 1 | 1 |
NUDT5 | R.TLHY*ECIVLVK.Q | 74 | Nudix-type motif 5 | 1:10.3 | NP_054861 | 2 | 1 |
PFKFB3 | R.ISCY*EASYQPLDPDKCDR.D | 194 | 6-Phosphofructo-2-kinase | >1:8 | NP_004557 | Not found | 3 |
PKM2 | R.TATESFASDPILY*RPVAVALDTKGPEIR.T | 105 | Pyruvate kinase 3 | 1:4.56 | NP_002645 | 1 | 1 |
SUCLA2 | K.SPDEAY*AIAK.K | 84 | succinate-CoA ligase, ADP-forming, β sub | >1:2.64 | NP_003841 | Not found | 1 |
Metabolism of nucleic acids | |||||||
HIST1H4I | R.ISGLIY*EETR.G | 52 | H4 histone family | 1:2.45 | NP_068803 | 4 | 1 |
HNRPF | K.ATENDIY*NFFSPLNPVR.V | 306 | Heterogeneous nuclear ribonucleoprotein F | >1:3 | NP_004957 | Not found | 2 |
MKI67IP | R.TGNSKGY*AFVEFESEDVAK.I | 88 | FHA domain interacting nucleolar phosphopro | 1:2.8 | NP_115766 | Not found | 1 |
PABP 1 | R.SLGY*AYVNFQQPADAER.A | 56 | Poly A binding protein, cytoplasmic 4 | >1:8 | NP_003810 | 2 | 1 |
POLR2A | R.LTHVY*DLCK.G | 145 | DNA directed RNA pol. II polyp. A | 1:3.58 | NP_000928 | 2 | 1 |
RNPS1 | K.GY*AYVEFENPDEAEK.A | 205 | RNA binding prot S1, serine-rich domain | >1:4 | NP_542161 | 4 | 1 |
SFPQ | R.FAQHGTFEY*EYSQR.W | 488 | Splicing factor proline/glutamine rich (polypyri | 1:3.63 | NP_005057 | 2 | 3 |
SYNCRIP | K.LKDY*AFIHFDERDGAVK.A | 373 | Synaptotagmin binding, cytoplasmic RNA inte | 1:3.88 | NP_006363 | Not found | 2 |
Regulation of translation | |||||||
PHF19 | K.LTEGQY*VLCR.W | 45 | PHD finger protein 19 | 1:3.5 | NP_082992 | Not found | 2 |
PHB2 | R.IPWFQY*PIIYDIR.A | 77 | Prohibitin 2 | 1:3.43 | NP_009204 | Not found | 1 |
PHB2 | R.LGLDY*EER.V | 128 | Prohibitin 2 | 1:1.93 | NP_009204 | Not found | 3 |
EEF1A1 | K.STTTGHLIY*K.C | 29 | Eukaryotic elongation factor 1 α 1 | >1:3 | NP_001393 | Not found | 3 |
EIF3S2 | K.SYSSGGEDGY*VR.I | 308 | Eukaryotic translation initiation factor 3 | >1:13 | NP_003748 | 2 | 1 |
EIF3S9 | K.NGDY*LCVK.V | 525 | Eukaryotic translation initiation factor 3, subun | 1:3.75 | NP_003742 | 2 | 1 |
EIF3S7 | R.NLAMEATY*INHNFSQQCLR.M | 318 | Eukaryotic translation initiation factor 3,subun | 1:2.68 | NP_003744 | 4 | 1 |
KNTC2 | R.AQVY*VPLKELLNETEEEINK.A | 458 | Kinetochore associated 2 | >1:5 | NP_006092 | Not found | 1 |
Ribosomal proteins | |||||||
RPL18A | K.SSGEIVY*CGQVFEK.S | 63 | Ribosomal protein L18a | 1:3.16 | NP_000971 | 1 | 1 |
RPL31 | R.NEDEDSPNKLY*TLVTYVPVTTFK.N | 103 | Ribosomal protein L31 | 1:2.87 | NP_000984 | 1 | 1 |
RPL7 | R.IVEPY*IAWGYPNLK.S | 139 | Ribosomal protein L7 | 1:2.10 | NP_000962 | 2 | 1 |
RPL8 | R.ASGNY*ATVISHNPETK.K | 133 | Ribosomal protein L8 | 1:3.15 | NP_000964 | 1 | 1 |
RPLP0 | K.IIQLLDDY*PK.C | 24 | Ribosomal protein P0 | 1:5.23 | NP_000993 | 4 | 1 |
RPS10 | R.IAIY*ELLFK.E | 12 | Ribosomal protein S10 | 1:2.52 | NP_001005 | Not found | 1 |
RPS13 | K.LTSDDVKEQIY*K.L | 38 | Ribosomal protein S13 | 1:1.8 | NP_001008 | Not found | 1 |
Transcription factors | |||||||
DCP1A | R.SASPY*HGFTIVNR.L | 64 | DCP1 decapping enzyme homolog A | 1:2.24 | NP_060873 | Not found | 1 |
STAT3 iso1 | K.YCRPESQEHPEADPGSAAPY*LK.T | 705 | Signal transducer and activator of transcriptio | 1:13.23 | NP_644805 | 1 | 1 |
STAT3 iso2 | K.YCRPESQEHPEADPGAAPY*LK.T | 704 | Signal transducer and activator of transcriptio | 1:13.57 | NP_003141 | 4 | 1 |
Ubiquitin-proteasome system | |||||||
PSMA2 | K.LVQIEY*ALAAVAGGAPSVGIK.A | 98 | Proteasome subunit α type 2 | 1:4.37 | NP_002778 | 2 | 1 |
PSMA2 | R.KLAQQYY*LVYQEPIPTAQLVQR.V | 24 | Proteasome subunit α type 2 | 1:3.18 | NP_002778 | 2 | 1 |
Others | |||||||
ANXA2 | K.SLY*YYIQQDTK.G | 316 | Annexin A2 | 1:1.91 | NP_004030 | 2 | 1 |
GSDMDC1 | R.SRGDNVY*VVTEVLQTQK.E | 71 | Gasdermin domain containing 1 | 1:3.27 | NP_079012 | Not found | 1 |
FAM62B | R.NLIAFSEDGSDPY*VR.M | 796 | Family with sequence similarity 62 member B | >1:3 | NP_065779 | 2 | 3 |
WDR1 | K.AHDGGIY*AISWSPDSTHLLSASGDK.T | 98 | WD repeat-containing protein 1 | 1:3.58 | NP_005103 | 2 | 1 |
Peptides with no significant change | |||||||
Kinases | |||||||
DYRK1A | R.KVYNDGYDDDNY*DYIVK.N | 145 | Dual-specificity tyr. phosphorylation regulated | 1:1.15 | NP_001387 | 2 | 1 |
DYRK1A | R.IYQY*IQSR.F | 321 | Dual-specificity tyr. phosphorylation regulated | 1:1.36 | NP_001387 | 1 | 1 |
GSK3 | R.GEPNVSY*ICSR.Y | 216 | Glycogen synthase kinase 3 α | 1:1.15 | NP_063937 | 1 | 1 |
HIPK1 | K.AVCSTY*LQSR.Y | 352 | Homeodomain interacting protein kinase 1 | 1:1.15 | NP_689909 | 2 | 1 |
HIPK3 | K.TVCSTY*LQSR.Y | 359 | Homeodomain interacting protein kinase 3 | 1:0.99 | NP_005725 | 3 | 1 |
PRPF4B | K.LCDFGSASHVADNDITPY*LVSR.F | 849 | Serine/threonine-protein kinase PRP4K | 1:1.02 | NP_003904 | 1 | 1 |
SRC | R.LIEDNEY*TAR.Q | 419 (416) | v-src sarcoma viral Oncogene homolog | 1:1.10 | NP_005408 | Not found | Not found |
Adaptors | |||||||
SHC | R.ELFDDPSY*VNVQNLDK.A | 318 | SHC 1 | 1:1.44 | NP_003020 | 1 | 1 |
Chaperones | |||||||
HSPD1 | R.GYISPY*FINTSK.G | 227 | Heat shock 60 kDa protein 1 (chaperonin) | 1:1.35 | NP_955472 | Not found | 1 |
HSP90AA1 | K.HIY*YITGETK.D | 492 | Heat shock 90 kDa protein | 1:1.18 | NP_005339 | Not found | 1 |
Cytokines | |||||||
PBEF | K.VY*SYFECR.E | 34 | Pre-B-cell colony enhancing factor 1 | 1:1.02 | NP_005737 | 2 | 1 |
Energy metabolism | |||||||
GDI2 | R.TDDYLDQPCY*ETINR.I | 203 | GDP dissociation inhibitor 2 | 1:1.46 | NP_001485 | 2 | 1 |
RAN | K.SNY*NFEKPFLWLAR.K | 155 | ras-related nuclear protein | 1:1.12 | NP_006316 | Not found | 1 |
WRNIP1 | R.MLEGGEDPLY*VAR.R | 534 | Werner helicase interacting protein 1 | 1:1.20 | NP_064520 | 2 | 1 |
Gene symbol . | Peptide . | PTyr site . | Protein . | *Average H:L . | NCBI access no. . | shALK . | ALK inhibitor . |
---|---|---|---|---|---|---|---|
Peptides that decrease when ALK is reduced | |||||||
Kinases | |||||||
ALK | R.TSTIMTDYNPNY*CFAGK | 1096 | Anaplastic lymphoma kinase | 1:6.20 | NP_004295 | 1 | 1 |
ALK | R.NKPTSLWNPTY*GSWFTEKPTK | 1507 | Anaplastic lymphoma kinase | 1:3.72 | NP_004295 | 2 | 1 |
CDC2 | K.IEKIGEGTY*GVVYK | 15 | Cell division cycle 2 protein | 1:2.7 | NP_203698 | 2 | 1 |
CDK2 | K.VEKIGEGTY*GVVYK | 15 | Cyclin dependent kinase 2 | >1:6 | NP_001789 | 2 | 1 |
ERK1/MAPK3 | R.IADPEHDHTGFLTEY*VATR | 187 | Mitogen-activated protein kinase 3 | 1:2.07 | NP_002737 | Not found | 2 |
p38/MAPK14 | R.HTDDEMTGY*VATR | 182 | Mitogen-activated protein kinase 14 | 1:3.22 | NP_620581 | 2 | 1 |
Adaptors | |||||||
HGS | R.VCEPCY*EQLNR | 216 | HGF regulated tyrosine kinase substrate | >1:4 | NP_004703 | Not found | 1 |
PAG | K.SGQSLTVPESTY*TSIQGDPQR | 341 | Phosphoprotein associated with glycosphingo | 1.47:1 | NP_060910 | Not found | 3 |
PARD3 | R.DVTIGGSAPIY*VK | 489 | par-3 partitioning defective 3 homolog | >1:4 | NP_062565 | Not found | 2 |
Cytoskeletal proteins | |||||||
ACTB | R.KDLY*ANTVLSGGTTMYPGIADR.M | 294 | Actin, β | 1:5.71 | NP_001092 | 1 | Not found |
ACTB | K.EKLCY*VALDFEQEMATAASSSSLEK.S | 218 | Actin, β | >1:3 | NP_001092 | 1 | 1 |
CORO1C | R.YFEITDESPY*VHYLNTFSSK.E | 301 | Coronin, actin binding protein, 1C | 1:2.47 | NP_055140 | 3 | 1 |
VASP | R.VQIY*HNPTANSFR.V | 39 | Vasodilator-stimulated phosphoprotein | >1:9 | NP_003361 | 1 | 1 |
VIM | R.FANY*IDKVR.F | 117 | Vimentin | >1:6 | NP_003371 | 2 | 1 |
Chaperones | |||||||
HSP90AB1 | K.SIY*YITGESK.E | 484 | Heat shock protein 90kDa α | 1:2.74 | NP_031381 | 4 | 1 |
HSPA2 | R.TTPSY*VAFTDTER.L | 43 | Heat shock 70kDa protein 2 | >1:2 | NP_068814 | Not found | 1 |
HSPA4 | K.LKKEDIY*AVEIVGGATR.I | 336 | Heat shock 70kDa protein 4 | 1:2.66 | NP_002145 | 2 | 1 |
TRAP1 | R.NIY*YLCAPNR.H | 498 | TNF receptor-associated protein 1 | 1:2.9 | NP_057376 | 1 | 1 |
Cytokines | |||||||
PBEF | K.YLLETSGNLDGLEY*KLHDFGYR.G | 188 | Pre-B-cell colony enhancing factor 1 | 1:2.04 | NP_005737 | 1 | 1 |
Energy metabolism | |||||||
RASA1 | K.HFTNPY*CNIYLNSVQVAK.T | 615 | RAS p21 protein activator 1 | 1:3.25 | NP_072179 | ||
Metabolic enzymes | |||||||
ACLY | R.TTDGVY*EGVAIGGDRYPGSTFMDHVLR.Y | 682 | ATP cytrate lyase | 1:4.27 | NP_001087 | 1 | 1 |
ACP1 | K.QLIIEDPYYGNDSDFETVY*QQCVR.C | 143 | Acidic phosphatase 1 | 1:5.2 | NP_004291 | 2 | 1 |
ATIC | VVACNLyPFVK | 104 | AICAR formyltransferase/IMP Chase | 1:3.70 | NP_004035 | 1 | 1 |
ELP3 | R.NLHDALSGHTSNNIY*EAVK.Y | 202 | Elongation protein 3 | 1:5.57 | NP_060561 | 2 | 1 |
ENO1 | K.SFIKDY*PVVSIEDPFDQDDWGAWQK.F | 287 | Enolase 1 | 1:2.91 | NP_001419 | 1 | 1 |
GBE1 | R.EGDNVNY*DWIHWDPEHSYEFK.H | 173 | Glucan (1,4-α-), branching enzyme 1 | 1:1.86 | NP_000149 | 3 | 1 |
LDHA | K.QVVESAY*EVIK.L | 239 | Lactate dehydrogenase A | 1:3.03 | NP_005557 | 2 | 1 |
LDHB | K.MVVESAY*EVIK.L | 240 | Lactate dehydrogenase B | 1:4.00 | NP_002291 | 1 | 1 |
NIT2 | K.TLSPGDSFSTFDTPY*CR.V | 145 | Nitrilase family, member 2 | 1:4.14 | NP_064587 | 1 | 1 |
NUDT5 | R.TLHY*ECIVLVK.Q | 74 | Nudix-type motif 5 | 1:10.3 | NP_054861 | 2 | 1 |
PFKFB3 | R.ISCY*EASYQPLDPDKCDR.D | 194 | 6-Phosphofructo-2-kinase | >1:8 | NP_004557 | Not found | 3 |
PKM2 | R.TATESFASDPILY*RPVAVALDTKGPEIR.T | 105 | Pyruvate kinase 3 | 1:4.56 | NP_002645 | 1 | 1 |
SUCLA2 | K.SPDEAY*AIAK.K | 84 | succinate-CoA ligase, ADP-forming, β sub | >1:2.64 | NP_003841 | Not found | 1 |
Metabolism of nucleic acids | |||||||
HIST1H4I | R.ISGLIY*EETR.G | 52 | H4 histone family | 1:2.45 | NP_068803 | 4 | 1 |
HNRPF | K.ATENDIY*NFFSPLNPVR.V | 306 | Heterogeneous nuclear ribonucleoprotein F | >1:3 | NP_004957 | Not found | 2 |
MKI67IP | R.TGNSKGY*AFVEFESEDVAK.I | 88 | FHA domain interacting nucleolar phosphopro | 1:2.8 | NP_115766 | Not found | 1 |
PABP 1 | R.SLGY*AYVNFQQPADAER.A | 56 | Poly A binding protein, cytoplasmic 4 | >1:8 | NP_003810 | 2 | 1 |
POLR2A | R.LTHVY*DLCK.G | 145 | DNA directed RNA pol. II polyp. A | 1:3.58 | NP_000928 | 2 | 1 |
RNPS1 | K.GY*AYVEFENPDEAEK.A | 205 | RNA binding prot S1, serine-rich domain | >1:4 | NP_542161 | 4 | 1 |
SFPQ | R.FAQHGTFEY*EYSQR.W | 488 | Splicing factor proline/glutamine rich (polypyri | 1:3.63 | NP_005057 | 2 | 3 |
SYNCRIP | K.LKDY*AFIHFDERDGAVK.A | 373 | Synaptotagmin binding, cytoplasmic RNA inte | 1:3.88 | NP_006363 | Not found | 2 |
Regulation of translation | |||||||
PHF19 | K.LTEGQY*VLCR.W | 45 | PHD finger protein 19 | 1:3.5 | NP_082992 | Not found | 2 |
PHB2 | R.IPWFQY*PIIYDIR.A | 77 | Prohibitin 2 | 1:3.43 | NP_009204 | Not found | 1 |
PHB2 | R.LGLDY*EER.V | 128 | Prohibitin 2 | 1:1.93 | NP_009204 | Not found | 3 |
EEF1A1 | K.STTTGHLIY*K.C | 29 | Eukaryotic elongation factor 1 α 1 | >1:3 | NP_001393 | Not found | 3 |
EIF3S2 | K.SYSSGGEDGY*VR.I | 308 | Eukaryotic translation initiation factor 3 | >1:13 | NP_003748 | 2 | 1 |
EIF3S9 | K.NGDY*LCVK.V | 525 | Eukaryotic translation initiation factor 3, subun | 1:3.75 | NP_003742 | 2 | 1 |
EIF3S7 | R.NLAMEATY*INHNFSQQCLR.M | 318 | Eukaryotic translation initiation factor 3,subun | 1:2.68 | NP_003744 | 4 | 1 |
KNTC2 | R.AQVY*VPLKELLNETEEEINK.A | 458 | Kinetochore associated 2 | >1:5 | NP_006092 | Not found | 1 |
Ribosomal proteins | |||||||
RPL18A | K.SSGEIVY*CGQVFEK.S | 63 | Ribosomal protein L18a | 1:3.16 | NP_000971 | 1 | 1 |
RPL31 | R.NEDEDSPNKLY*TLVTYVPVTTFK.N | 103 | Ribosomal protein L31 | 1:2.87 | NP_000984 | 1 | 1 |
RPL7 | R.IVEPY*IAWGYPNLK.S | 139 | Ribosomal protein L7 | 1:2.10 | NP_000962 | 2 | 1 |
RPL8 | R.ASGNY*ATVISHNPETK.K | 133 | Ribosomal protein L8 | 1:3.15 | NP_000964 | 1 | 1 |
RPLP0 | K.IIQLLDDY*PK.C | 24 | Ribosomal protein P0 | 1:5.23 | NP_000993 | 4 | 1 |
RPS10 | R.IAIY*ELLFK.E | 12 | Ribosomal protein S10 | 1:2.52 | NP_001005 | Not found | 1 |
RPS13 | K.LTSDDVKEQIY*K.L | 38 | Ribosomal protein S13 | 1:1.8 | NP_001008 | Not found | 1 |
Transcription factors | |||||||
DCP1A | R.SASPY*HGFTIVNR.L | 64 | DCP1 decapping enzyme homolog A | 1:2.24 | NP_060873 | Not found | 1 |
STAT3 iso1 | K.YCRPESQEHPEADPGSAAPY*LK.T | 705 | Signal transducer and activator of transcriptio | 1:13.23 | NP_644805 | 1 | 1 |
STAT3 iso2 | K.YCRPESQEHPEADPGAAPY*LK.T | 704 | Signal transducer and activator of transcriptio | 1:13.57 | NP_003141 | 4 | 1 |
Ubiquitin-proteasome system | |||||||
PSMA2 | K.LVQIEY*ALAAVAGGAPSVGIK.A | 98 | Proteasome subunit α type 2 | 1:4.37 | NP_002778 | 2 | 1 |
PSMA2 | R.KLAQQYY*LVYQEPIPTAQLVQR.V | 24 | Proteasome subunit α type 2 | 1:3.18 | NP_002778 | 2 | 1 |
Others | |||||||
ANXA2 | K.SLY*YYIQQDTK.G | 316 | Annexin A2 | 1:1.91 | NP_004030 | 2 | 1 |
GSDMDC1 | R.SRGDNVY*VVTEVLQTQK.E | 71 | Gasdermin domain containing 1 | 1:3.27 | NP_079012 | Not found | 1 |
FAM62B | R.NLIAFSEDGSDPY*VR.M | 796 | Family with sequence similarity 62 member B | >1:3 | NP_065779 | 2 | 3 |
WDR1 | K.AHDGGIY*AISWSPDSTHLLSASGDK.T | 98 | WD repeat-containing protein 1 | 1:3.58 | NP_005103 | 2 | 1 |
Peptides with no significant change | |||||||
Kinases | |||||||
DYRK1A | R.KVYNDGYDDDNY*DYIVK.N | 145 | Dual-specificity tyr. phosphorylation regulated | 1:1.15 | NP_001387 | 2 | 1 |
DYRK1A | R.IYQY*IQSR.F | 321 | Dual-specificity tyr. phosphorylation regulated | 1:1.36 | NP_001387 | 1 | 1 |
GSK3 | R.GEPNVSY*ICSR.Y | 216 | Glycogen synthase kinase 3 α | 1:1.15 | NP_063937 | 1 | 1 |
HIPK1 | K.AVCSTY*LQSR.Y | 352 | Homeodomain interacting protein kinase 1 | 1:1.15 | NP_689909 | 2 | 1 |
HIPK3 | K.TVCSTY*LQSR.Y | 359 | Homeodomain interacting protein kinase 3 | 1:0.99 | NP_005725 | 3 | 1 |
PRPF4B | K.LCDFGSASHVADNDITPY*LVSR.F | 849 | Serine/threonine-protein kinase PRP4K | 1:1.02 | NP_003904 | 1 | 1 |
SRC | R.LIEDNEY*TAR.Q | 419 (416) | v-src sarcoma viral Oncogene homolog | 1:1.10 | NP_005408 | Not found | Not found |
Adaptors | |||||||
SHC | R.ELFDDPSY*VNVQNLDK.A | 318 | SHC 1 | 1:1.44 | NP_003020 | 1 | 1 |
Chaperones | |||||||
HSPD1 | R.GYISPY*FINTSK.G | 227 | Heat shock 60 kDa protein 1 (chaperonin) | 1:1.35 | NP_955472 | Not found | 1 |
HSP90AA1 | K.HIY*YITGETK.D | 492 | Heat shock 90 kDa protein | 1:1.18 | NP_005339 | Not found | 1 |
Cytokines | |||||||
PBEF | K.VY*SYFECR.E | 34 | Pre-B-cell colony enhancing factor 1 | 1:1.02 | NP_005737 | 2 | 1 |
Energy metabolism | |||||||
GDI2 | R.TDDYLDQPCY*ETINR.I | 203 | GDP dissociation inhibitor 2 | 1:1.46 | NP_001485 | 2 | 1 |
RAN | K.SNY*NFEKPFLWLAR.K | 155 | ras-related nuclear protein | 1:1.12 | NP_006316 | Not found | 1 |
WRNIP1 | R.MLEGGEDPLY*VAR.R | 534 | Werner helicase interacting protein 1 | 1:1.20 | NP_064520 | 2 | 1 |
Average H:L indicates SILAC quantification performed on samples treated with ALK shRNA.
1Phosphopeptides that are present both in CEP11988 and CEP14083, in shALK− and shALK+.
2Phosphopeptides that are present in CEP11988 and in shALK−, but not in CEP14083 and shALK+.
3Phosphopeptides that are present in CEP14083 and shALK+, but not in CEP11988 and in shALK−.
4Phosphopeptides detected twice with ambiguous results.