Adverse effects associated with imatinib dose escalation in the total population: N = 84
| Adverse events . | Patients, no. (%) . | |
|---|---|---|
| All grades . | Grades 3/4 . | |
| Nonhematologic toxicity | ||
| Fluid retention | 10 (12) | 0 (0) |
| Muscle cramps | 7 (8) | 1 (1) |
| Diarrhea | 5 (6) | 0 (0) |
| Nausea | 4 (5) | 0 (0) |
| Fatigue | 4 (5) | 0 (0) |
| Rash | 4 (5) | 1 (1) |
| Extremity pain | 2 (2) | 0 (0) |
| Dizziness | 2 (2) | 0 (0) |
| Increase creatinine | 1 (1) | 0 (0) |
| Bleeding | 1 (1) | 1 (1) |
| Hematologic toxicity | ||
| Thrombocytopenia | 11 (13) | 4 (5) |
| Leukopenia | 4 (5) | 4 (5) |
| Anemia | 11 (13) | 1 (1) |
| Adverse events . | Patients, no. (%) . | |
|---|---|---|
| All grades . | Grades 3/4 . | |
| Nonhematologic toxicity | ||
| Fluid retention | 10 (12) | 0 (0) |
| Muscle cramps | 7 (8) | 1 (1) |
| Diarrhea | 5 (6) | 0 (0) |
| Nausea | 4 (5) | 0 (0) |
| Fatigue | 4 (5) | 0 (0) |
| Rash | 4 (5) | 1 (1) |
| Extremity pain | 2 (2) | 0 (0) |
| Dizziness | 2 (2) | 0 (0) |
| Increase creatinine | 1 (1) | 0 (0) |
| Bleeding | 1 (1) | 1 (1) |
| Hematologic toxicity | ||
| Thrombocytopenia | 11 (13) | 4 (5) |
| Leukopenia | 4 (5) | 4 (5) |
| Anemia | 11 (13) | 1 (1) |