Results of univariate and multivariate analyses of graft and patient factors influencing aGVHD grades II to IV and cGVHD
| Variable . | Univariate analysis (includes only significant variables) . | Multivariate analysis (includes only significant variables) . | Favorable in multivariate analysis . | ||||
|---|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | ||
| aGVHD grades II-IV* | |||||||
| Date of transplantation | |||||||
| After January 1, 2001 | 2.07 | 0.99-4.35 | .05 | ||||
| Before January 1, 2001 | 1.000 | ||||||
| ABO match | |||||||
| Mismatched | 1.88 | 1.14-3.08 | .01 | 1.92 | 1.17-3.15 | < .01 | ABO matched |
| Matched | 1.00 | 1.00 | |||||
| cGVHD† | |||||||
| CD34, × 105/kg | |||||||
| More than 2.1 | 0.54 | 0.29-1.02 | .06 | 0.43 | 0.22-0.82 | .01 | CD34 > 2.1 |
| 2.1 or less | 1.00 | 1.00 | |||||
| Recipient ethnicity | |||||||
| Other | 2.50 | 1.19-5.24 | .02 | 3.40 | 1.6-7.45 | .002 | White patient |
| White | 1.00 | 1.00 | |||||
| ABO match | |||||||
| Mismatched | 2.09 | 1.12-3.90 | .02 | 2.36 | 1.3-4.45 | .008 | ABO matched |
| Matched | 1.00 | 1.00 | |||||
| Variable . | Univariate analysis (includes only significant variables) . | Multivariate analysis (includes only significant variables) . | Favorable in multivariate analysis . | ||||
|---|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | ||
| aGVHD grades II-IV* | |||||||
| Date of transplantation | |||||||
| After January 1, 2001 | 2.07 | 0.99-4.35 | .05 | ||||
| Before January 1, 2001 | 1.000 | ||||||
| ABO match | |||||||
| Mismatched | 1.88 | 1.14-3.08 | .01 | 1.92 | 1.17-3.15 | < .01 | ABO matched |
| Matched | 1.00 | 1.00 | |||||
| cGVHD† | |||||||
| CD34, × 105/kg | |||||||
| More than 2.1 | 0.54 | 0.29-1.02 | .06 | 0.43 | 0.22-0.82 | .01 | CD34 > 2.1 |
| 2.1 or less | 1.00 | 1.00 | |||||
| Recipient ethnicity | |||||||
| Other | 2.50 | 1.19-5.24 | .02 | 3.40 | 1.6-7.45 | .002 | White patient |
| White | 1.00 | 1.00 | |||||
| ABO match | |||||||
| Mismatched | 2.09 | 1.12-3.90 | .02 | 2.36 | 1.3-4.45 | .008 | ABO matched |
| Matched | 1.00 | 1.00 | |||||
Grades II-IV aGVHD: Variables not found to be statistically significant in univariate analysis include performance status (< 80, ≥ 80), age (> 2 years, < 2 years), recipient sex, unit sex, sex matching (recipient/unit), cryopreserved cell dose × 107/kg (> 9.7, ≤ 9.7), reinfused cell dose × 107/kg (> 7.6, ≤ 7.6), reinfused CD34 × 105/kg (> 2.1, ≤ 2.1), reinfused CFUs × 104/kg (> 5.7, ≤ 5.7), reinfused CD3 × 106/kg (> 14.2, ≤ 14.2), recipient ethnicity, unit ethnicity, ethnicity matching (recipient/unit), HLA match (5/6 and 6/6, 3/6 and 4/6), recipient CMV serostatus, and recipient weight (< 12 kg, ≥ 12 kg).
cGVHD: Variables not found to be statistically significant in univariate analysis include performance status (< 80, ≥ 80), age (> 2 years, < 2 years), recipient sex, unit sex, cryopreserved cell dose × 107/kg (> 9.7, ≤ 9.7), reinfused cell dose × 107/kg (> 7.6, ≤ 7.6), reinfused CFUs × 104/kg (> 5.7, ≤ 5.7), reinfused CD3 × 106/kg (> 14.2, ≤ 14.2), date of transplantation (after 1/1/2001, before 1/1/2001), unit ethnicity, ethnicity matching (recipient/unit), HLA match (5/6 and 6/6, 3/6 and 4/6), recipient CMV serostatus, and recipient weight (< 12 kg, ≥ 12 kg).