Baseline participant characteristics by HDL-c quartile, LITE
| Characteristic . | HDL-c quartile, mg/dL, men . | P . | |||
|---|---|---|---|---|---|
| 9.6 to <35.6 . | 35.6 to <43.0 . | 43.0 to <52.0 . | 52.0 to 156 . | ||
| Age, y | 57.6 ± 0.2 | 58.8 ± 0.2 | 60.0 ± 0.2 | 60.6 ± 0.2 | <.001 |
| Race | |||||
| White | 1855 (88.2) | 1969 (83.9) | 1875 (79.6) | 1608 (68.4) | <.001 |
| African American | 248 (11.8) | 378 (16.1) | 482 (20.4) | 742 (31.6) | |
| Study | |||||
| ARIC | 1754 (83.4) | 1816 (77.4) | 1644 (69.7) | 1637 (69.7) | <.001 |
| CHS | 349 (16.6) | 531 (22.6) | 713 (30.3) | 713 (30.3) | |
| BMI, kg/m2 | |||||
| Less than 25 | 356 (16.9) | 583 (24.9) | 757 (32.2) | 1042 (44.4) | <.001 |
| 25 to less than 30 | 1070 (50.9) | 1227 (52.3) | 1150 (48.8) | 1012 (43.2) | |
| 30 or greater | 676 (32.2) | 534 (22.8) | 448 (19.0) | 290 (12.4) | |
| Diabetes | |||||
| Yes | 432 (20.6) | 335 (14.3) | 262 (11.1) | 220 (9.4) | <.001 |
| IFG | 346 (16.5) | 376 (16.1) | 299 (12.7) | 296 (12.6) | |
| No | 1317 (62.9) | 1628 (69.6) | 1790 (76.2) | 1829 (78.0) | |
| Factor VIIIc, % | 127.5 ± 0.8 | 124.9 ± 0.8 | 123.0 ± 0.8 | 125.8 ± 0.8 | .001 |
| Alcohol, g/wk | 36.6 ± 2.6 | 50.7 ± 2.6 | 66.0 ± 2.5 | 106.7 ± 2.6 | <.001 |
| Smoking, pack-years | 25.8 ± 0.6 | 24.3 ± 0.6 | 22.1 ± 0.6 | 22.7 ± 0.6 | <.001 |
| Lipid medication | 101 (4.8) | 88 (3.8) | 73 (3.1) | 50 (2.2) | <.001 |
| Characteristic . | HDL-c quartile, mg/dL, men . | P . | |||
|---|---|---|---|---|---|
| 9.6 to <35.6 . | 35.6 to <43.0 . | 43.0 to <52.0 . | 52.0 to 156 . | ||
| Age, y | 57.6 ± 0.2 | 58.8 ± 0.2 | 60.0 ± 0.2 | 60.6 ± 0.2 | <.001 |
| Race | |||||
| White | 1855 (88.2) | 1969 (83.9) | 1875 (79.6) | 1608 (68.4) | <.001 |
| African American | 248 (11.8) | 378 (16.1) | 482 (20.4) | 742 (31.6) | |
| Study | |||||
| ARIC | 1754 (83.4) | 1816 (77.4) | 1644 (69.7) | 1637 (69.7) | <.001 |
| CHS | 349 (16.6) | 531 (22.6) | 713 (30.3) | 713 (30.3) | |
| BMI, kg/m2 | |||||
| Less than 25 | 356 (16.9) | 583 (24.9) | 757 (32.2) | 1042 (44.4) | <.001 |
| 25 to less than 30 | 1070 (50.9) | 1227 (52.3) | 1150 (48.8) | 1012 (43.2) | |
| 30 or greater | 676 (32.2) | 534 (22.8) | 448 (19.0) | 290 (12.4) | |
| Diabetes | |||||
| Yes | 432 (20.6) | 335 (14.3) | 262 (11.1) | 220 (9.4) | <.001 |
| IFG | 346 (16.5) | 376 (16.1) | 299 (12.7) | 296 (12.6) | |
| No | 1317 (62.9) | 1628 (69.6) | 1790 (76.2) | 1829 (78.0) | |
| Factor VIIIc, % | 127.5 ± 0.8 | 124.9 ± 0.8 | 123.0 ± 0.8 | 125.8 ± 0.8 | .001 |
| Alcohol, g/wk | 36.6 ± 2.6 | 50.7 ± 2.6 | 66.0 ± 2.5 | 106.7 ± 2.6 | <.001 |
| Smoking, pack-years | 25.8 ± 0.6 | 24.3 ± 0.6 | 22.1 ± 0.6 | 22.7 ± 0.6 | <.001 |
| Lipid medication | 101 (4.8) | 88 (3.8) | 73 (3.1) | 50 (2.2) | <.001 |
| Characteristic . | HDL-c quartile, mg/dL, women . | P . | |||
|---|---|---|---|---|---|
| 11.6 to <46.2 . | 46.2 to <55.9 . | 55.9 to <67.4 . | 67.4 to 163 . | ||
| Age, y | 58.2 ± 0.2 | 58.9 ± 0.2 | 59.3 ± 0.2 | 58.9 ± 0.2 | <.001 |
| Race | |||||
| White | 2131 (75.0) | 2071 (73.8) | 2053 (73.6) | 2187 (74.4) | .627 |
| African American | 709 (25.0) | 734 (26.2) | 735 (26.4) | 753 (25.6) | |
| Study | |||||
| ARIC | 2179 (76.7) | 2030 (72.4) | 1968 (70.6) | 2124 (72.2) | <.001 |
| CHS | 661 (23.3) | 775 (27.6) | 820 (29.4) | 816 (27.8) | |
| BMI, kg/m2 | |||||
| Less than 25 | 684 (24.1) | 877 (31.3) | 1195 (42.9) | 1656 (56.4) | <.001 |
| 25 to less than 30 | 964 (34.0) | 971 (34.7) | 943 (33.9) | 867 (29.5) | |
| 30 or greater | 1189 (41.9) | 950 (34.0) | 647 (23.2) | 413 (14.1) | |
| Diabetes | |||||
| Yes | 623 (22.0) | 378 (13.5) | 232 (8.3) | 142 (4.8) | <.001 |
| IFG | 382 (13.5) | 297 (10.6) | 231 (8.3) | 186 (6.4) | |
| No | 1826 (64.5) | 2126 (75.9) | 2319 (83.4) | 2603 (88.8) | |
| Factor VIIIc, % | 138.6 ± 0.8 | 132.8 ± 0.8 | 129.6 ± 0.8 | 126.2 ± 0.8 | <.001 |
| Alcohol, g/wk | 10.7 ± 2.0 | 15.8 ± 2.0 | 21.9 ± 2.0 | 39.9 ± 1.9 | <.001 |
| Smoking, pack-years | 13.5 ± 0.3 | 10.6 ± 0.3 | 9.7 ± 0.3 | 9.7 ± 0.3 | <.001 |
| Lipid medication | 147 (5.2) | 97 (3.5) | 83 (3.0) | 84 (2.9) | <.001 |
| HRT use | 243 (8.8) | 332 (12.1) | 457 (16.9) | 869 (30.3) | <.001 |
| Characteristic . | HDL-c quartile, mg/dL, women . | P . | |||
|---|---|---|---|---|---|
| 11.6 to <46.2 . | 46.2 to <55.9 . | 55.9 to <67.4 . | 67.4 to 163 . | ||
| Age, y | 58.2 ± 0.2 | 58.9 ± 0.2 | 59.3 ± 0.2 | 58.9 ± 0.2 | <.001 |
| Race | |||||
| White | 2131 (75.0) | 2071 (73.8) | 2053 (73.6) | 2187 (74.4) | .627 |
| African American | 709 (25.0) | 734 (26.2) | 735 (26.4) | 753 (25.6) | |
| Study | |||||
| ARIC | 2179 (76.7) | 2030 (72.4) | 1968 (70.6) | 2124 (72.2) | <.001 |
| CHS | 661 (23.3) | 775 (27.6) | 820 (29.4) | 816 (27.8) | |
| BMI, kg/m2 | |||||
| Less than 25 | 684 (24.1) | 877 (31.3) | 1195 (42.9) | 1656 (56.4) | <.001 |
| 25 to less than 30 | 964 (34.0) | 971 (34.7) | 943 (33.9) | 867 (29.5) | |
| 30 or greater | 1189 (41.9) | 950 (34.0) | 647 (23.2) | 413 (14.1) | |
| Diabetes | |||||
| Yes | 623 (22.0) | 378 (13.5) | 232 (8.3) | 142 (4.8) | <.001 |
| IFG | 382 (13.5) | 297 (10.6) | 231 (8.3) | 186 (6.4) | |
| No | 1826 (64.5) | 2126 (75.9) | 2319 (83.4) | 2603 (88.8) | |
| Factor VIIIc, % | 138.6 ± 0.8 | 132.8 ± 0.8 | 129.6 ± 0.8 | 126.2 ± 0.8 | <.001 |
| Alcohol, g/wk | 10.7 ± 2.0 | 15.8 ± 2.0 | 21.9 ± 2.0 | 39.9 ± 1.9 | <.001 |
| Smoking, pack-years | 13.5 ± 0.3 | 10.6 ± 0.3 | 9.7 ± 0.3 | 9.7 ± 0.3 | <.001 |
| Lipid medication | 147 (5.2) | 97 (3.5) | 83 (3.0) | 84 (2.9) | <.001 |
| HRT use | 243 (8.8) | 332 (12.1) | 457 (16.9) | 869 (30.3) | <.001 |
Values are n (%) for categorical variables and mean plus or minus SEM for continuous variables.
BMI indicates body mass index; IFG, impaired fasting glucose; ARIC, Atherosclerosis Risk in Communities study; and CHS, Cardiovascular Health Study.