Characteristics of R-CHOP–treated and control patients (pre-R group) with FL according to MC content
| Characteristic . | R-CHOP group . | Control group (pre-R group) . | ||||||
|---|---|---|---|---|---|---|---|---|
| All patients, n = 98 . | Low MC content (≤ median), n = 51 . | High MC content (> median), n = 47 . | P . | All patients, n = 28 . | Low MC content, (≤ median), n = 15 . | High MC content, (> median), n = 13 . | P . | |
| Median MC content (range) | 1.5 (0-19) | 0.7 (0-1.5) | 3.8 (1.7-19) | NA | 1.5 (0-19) | 0.67 (0.4-10) | 3.8 (1.7-19) | NA |
| Mean MC content (SD) | 2.7 (3.4) | 0.7 (0.53) | 4.9 (3.8) | 2.9 (4.0) | 0.7 (0.50) | 5.4 (4.8) | ||
| Sex, n (%) | .064 | 1.000 | ||||||
| Female | 58 (59) | 35 (67) | 23 (49) | 18 (64) | 10 (67) | 8 (62) | ||
| Male | 40 (41) | 16 (31) | 24 (51) | 10 (36) | 5 (33) | 5 (38) | ||
| Age, n (%) | 1.000 | 1.000 | ||||||
| Younger than 60 y | 66 (67) | 34 (67) | 32 (68) | 23 (82) | 12 (80) | 11 (85) | ||
| 60 y or older | 32 (33) | 17 (33) | 15 (32) | 5 (18) | 3 (20) | 2 (15) | ||
| State of disease, n (%) | 1.000 | NA | ||||||
| Primary | 70 (71) | 36 (71) | 34 (72) | 28 (100) | 15 (100) | 13 (100) | ||
| Relapse | 28 (29) | 15 (29) | 13 (28) | 0 (0) | 0 (0) | 0 (0) | ||
| Grade, n (%) | .743 | 1.000 | ||||||
| I to II | 88 (90) | 45 (88) | 43 (91) | 26 (93) | 14 (93) | 12 (92) | ||
| III | 10 (10) | 6 (12) | 4 (9) | 2 (7) | 1 (7) | 1 (8) | ||
| R-FLIPI, n (%) | .114 | .639 | ||||||
| 0 to 2 | 62 (63) | 36 (70) | 26 (55.5) | 23 (82) | 13 (87) | 10 (77) | ||
| 3 to 5 | 29 (30) | 11 (22) | 18 (38.5) | 0 (0) | 0 (0) | 0 (0) | ||
| Missing | 7 (7) | 4 (8) | 3 (6) | 5 (18) | 2 (13) | 3 (23) | ||
| Tryptase, n (%) | <.001 | .008 | ||||||
| Median 6.6 or lower | 38 (52) | 28 (76) | 10 (28) | 9 (43) | 8 (73) | 1 (10) | ||
| Median greater than 6.6 | 35 (48) | 9 (24) | 26 (72) | 12 (57) | 3 (27) | 9 (90) | ||
| Characteristic . | R-CHOP group . | Control group (pre-R group) . | ||||||
|---|---|---|---|---|---|---|---|---|
| All patients, n = 98 . | Low MC content (≤ median), n = 51 . | High MC content (> median), n = 47 . | P . | All patients, n = 28 . | Low MC content, (≤ median), n = 15 . | High MC content, (> median), n = 13 . | P . | |
| Median MC content (range) | 1.5 (0-19) | 0.7 (0-1.5) | 3.8 (1.7-19) | NA | 1.5 (0-19) | 0.67 (0.4-10) | 3.8 (1.7-19) | NA |
| Mean MC content (SD) | 2.7 (3.4) | 0.7 (0.53) | 4.9 (3.8) | 2.9 (4.0) | 0.7 (0.50) | 5.4 (4.8) | ||
| Sex, n (%) | .064 | 1.000 | ||||||
| Female | 58 (59) | 35 (67) | 23 (49) | 18 (64) | 10 (67) | 8 (62) | ||
| Male | 40 (41) | 16 (31) | 24 (51) | 10 (36) | 5 (33) | 5 (38) | ||
| Age, n (%) | 1.000 | 1.000 | ||||||
| Younger than 60 y | 66 (67) | 34 (67) | 32 (68) | 23 (82) | 12 (80) | 11 (85) | ||
| 60 y or older | 32 (33) | 17 (33) | 15 (32) | 5 (18) | 3 (20) | 2 (15) | ||
| State of disease, n (%) | 1.000 | NA | ||||||
| Primary | 70 (71) | 36 (71) | 34 (72) | 28 (100) | 15 (100) | 13 (100) | ||
| Relapse | 28 (29) | 15 (29) | 13 (28) | 0 (0) | 0 (0) | 0 (0) | ||
| Grade, n (%) | .743 | 1.000 | ||||||
| I to II | 88 (90) | 45 (88) | 43 (91) | 26 (93) | 14 (93) | 12 (92) | ||
| III | 10 (10) | 6 (12) | 4 (9) | 2 (7) | 1 (7) | 1 (8) | ||
| R-FLIPI, n (%) | .114 | .639 | ||||||
| 0 to 2 | 62 (63) | 36 (70) | 26 (55.5) | 23 (82) | 13 (87) | 10 (77) | ||
| 3 to 5 | 29 (30) | 11 (22) | 18 (38.5) | 0 (0) | 0 (0) | 0 (0) | ||
| Missing | 7 (7) | 4 (8) | 3 (6) | 5 (18) | 2 (13) | 3 (23) | ||
| Tryptase, n (%) | <.001 | .008 | ||||||
| Median 6.6 or lower | 38 (52) | 28 (76) | 10 (28) | 9 (43) | 8 (73) | 1 (10) | ||
| Median greater than 6.6 | 35 (48) | 9 (24) | 26 (72) | 12 (57) | 3 (27) | 9 (90) | ||
For the pre-R group, initial diagnostic FLIPI scores are shown.
R-FLIPI indicates Follicular Lymphoma Prognostic Index before R-CHOP therapy; and NA, not applicable.