Univariate and multivariate analysis of high EVI1 expression as prognostic factor for survival
| . | EFS . | DFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | (95% CI) . | P . | HR . | (95% CI) . | P . | HR . | (95% CI) . | P . | |
| Univariable analysis, high EVI1 expression* | 2.17 | (1.55-3.03) | <.001 | 2.26 | (1.46-3.50) | <.001 | 1.91 | (1.34-2.72) | <.001 |
| Multivariable analysis | |||||||||
| Intermediate† | 1.62 | (1.17-2.26) | .004 | 1.91 | (1.30-2.82) | .001 | 1.84 | (1.27-2.68) | .001 |
| Unfavorable† | 2.90 | (1.88-4.49) | <.001 | 3.8 | (2.27-6.36) | <.001 | 3.46 | (2.14-5.60) | <.001 |
| Age | |||||||||
| 35 to 50 y | 1.03 | (0.78-1.35) | .84 | 1.10 | (0.81-1.52) | .53 | 1.22 | (0.90-1.65) | .20 |
| Older than 50 y | 1.23 | (0.94-1.60) | .13 | 1.17 | (0.86-1.60) | .33 | 1.48 | (1.11-1.98) | .007 |
| FLT3 ITD‡ | 1.40 | (1.11-1.77) | .005 | 1.25 | (0.93-1.67) | .13 | 1.55 | (1.21-1.99) | <.001 |
| Monosomy 7§ | 1.37 | (0.89-2.11) | .15 | 1.05 | (0.58-1.89) | .87 | 1.35 | (0.86-2.13) | .20 |
| MLL translocation‖ | 0.68 | (0.35-1.29) | .24 | 0.67 | (0.32-1.39) | .28 | 0.79 | (0.39-1.56) | .49 |
| High EVI1 expression* | 1.88 | (1.29-2.76) | .002 | 2.14 | (1.29-3.54) | .006 | 1.47 | (0.98-2.21) | .072 |
| . | EFS . | DFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | (95% CI) . | P . | HR . | (95% CI) . | P . | HR . | (95% CI) . | P . | |
| Univariable analysis, high EVI1 expression* | 2.17 | (1.55-3.03) | <.001 | 2.26 | (1.46-3.50) | <.001 | 1.91 | (1.34-2.72) | <.001 |
| Multivariable analysis | |||||||||
| Intermediate† | 1.62 | (1.17-2.26) | .004 | 1.91 | (1.30-2.82) | .001 | 1.84 | (1.27-2.68) | .001 |
| Unfavorable† | 2.90 | (1.88-4.49) | <.001 | 3.8 | (2.27-6.36) | <.001 | 3.46 | (2.14-5.60) | <.001 |
| Age | |||||||||
| 35 to 50 y | 1.03 | (0.78-1.35) | .84 | 1.10 | (0.81-1.52) | .53 | 1.22 | (0.90-1.65) | .20 |
| Older than 50 y | 1.23 | (0.94-1.60) | .13 | 1.17 | (0.86-1.60) | .33 | 1.48 | (1.11-1.98) | .007 |
| FLT3 ITD‡ | 1.40 | (1.11-1.77) | .005 | 1.25 | (0.93-1.67) | .13 | 1.55 | (1.21-1.99) | <.001 |
| Monosomy 7§ | 1.37 | (0.89-2.11) | .15 | 1.05 | (0.58-1.89) | .87 | 1.35 | (0.86-2.13) | .20 |
| MLL translocation‖ | 0.68 | (0.35-1.29) | .24 | 0.67 | (0.32-1.39) | .28 | 0.79 | (0.39-1.56) | .49 |
| High EVI1 expression* | 1.88 | (1.29-2.76) | .002 | 2.14 | (1.29-3.54) | .006 | 1.47 | (0.98-2.21) | .072 |
P values were calculated using the Cox regression model.
HR indicates hazard ratio with high EVI1 expression; CI, confidence interval; EFS, event-free survival; DFS, disease-free survival; OS, overall survival; and FLT3 ITD, FLT3 gene internal tandem duplication.
High EVI1 expression versus no EVI1 expression.
Cytogenetic risk versus favorable cytogenetic risk.
FLT3 ITD versus no FLT3 ITD.
Monosomy 7 versus no monosomy 7.
MLL translocation versus no MLL translocation.