Table 1

Clinicopathologic characteristics of sample sets

Clinicopathologic parameterTraining set, n = 65Test set, n = 72
Sex, no. (%)   
    Male 28 (43) 27/72 (38) 
    Female 37 (57) 45/72 (63) 
Age,* y [median (range)] 43 (16-60) 49 (27-60) 
WBC, ×1000/μL [median (range)] 31 (0.5-238) 14 (0.8-156) 
LDH,* U/L [median (range)] 553 (139-6676) 454 (133-1941) 
Preceding malignancy 0/60 1/66 
FAB n/N (%)   
    M0 6/64 (9) 5/65 (8) 
    M1 17/64 (27) 11/65 (17) 
    M2 15/64 (23) 21/65 (32) 
    M4 16/64 (25) 17/65 (26) 
    M5 10/64 (16) 9/65 (14) 
    M6 0/64 (0) 2/65 (3) 
FLT3-ITD mutation n/N (%) 28/64 (44) 22/63 (35) 
FLT3-TKD mutation n/N (%) 14/64 (22) 3/63 (5) 
MLL-PTD mutation, n/N (%) 4/65 (6) 5/65 (8) 
CEBPA mutation n/N (%) 6/56 (11) 10/60 (17) 
NPM1 mutation n/N (%) 34/61 (56) 32/60 (53) 
Median follow-up,§ d   
    All patients 405 515 
    Survivors 1360 785 
Median survival time,§405 675 
Median remission duration,§920 615 
Clinicopathologic parameterTraining set, n = 65Test set, n = 72
Sex, no. (%)   
    Male 28 (43) 27/72 (38) 
    Female 37 (57) 45/72 (63) 
Age,* y [median (range)] 43 (16-60) 49 (27-60) 
WBC, ×1000/μL [median (range)] 31 (0.5-238) 14 (0.8-156) 
LDH,* U/L [median (range)] 553 (139-6676) 454 (133-1941) 
Preceding malignancy 0/60 1/66 
FAB n/N (%)   
    M0 6/64 (9) 5/65 (8) 
    M1 17/64 (27) 11/65 (17) 
    M2 15/64 (23) 21/65 (32) 
    M4 16/64 (25) 17/65 (26) 
    M5 10/64 (16) 9/65 (14) 
    M6 0/64 (0) 2/65 (3) 
FLT3-ITD mutation n/N (%) 28/64 (44) 22/63 (35) 
FLT3-TKD mutation n/N (%) 14/64 (22) 3/63 (5) 
MLL-PTD mutation, n/N (%) 4/65 (6) 5/65 (8) 
CEBPA mutation n/N (%) 6/56 (11) 10/60 (17) 
NPM1 mutation n/N (%) 34/61 (56) 32/60 (53) 
Median follow-up,§ d   
    All patients 405 515 
    Survivors 1360 785 
Median survival time,§405 675 
Median remission duration,§920 615 

Significant differences between test and training sets:

*

P< .05 (Student t test).

P< .01 (Student t test).

P< .01 (Fisher exact test).

Estimated from Kaplan-Meier curve.

§

P = .01 (Log-rank test).

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