Patient characteristics
| . | Chronic GVHD(n = 52) . | No GVHD (controls)(n = 28) . | P . |
|---|---|---|---|
| Mean age, y (SD) | 11.5 (5.5) | 9.4 (6.3) | .14 |
| Sex | |||
| Male | 34 (65%) | 17 (61%) | .81 |
| Female | 18 (35%) | 11 (39%) | |
| Donor source | |||
| Bone marrow | 24 (46%) | 17 (61%) | .28 |
| Peripheral blood | 18 (35%) | 5 (18%) | |
| Umbilical cord blood | 10 (19%) | 6 (21%) | |
| Donor type | |||
| Related donor | 22 (43%) | 20 (71%) | .02 |
| Unrelated donor | 29 (57%) | 8 (29%) | |
| Acute GVHD | |||
| Yes | 33 (65%) | 12 (43%) | .10 |
| No | 18 (35%) | 16 (57%) | |
| cGVHD onset time (mean, SD) | |||
| Early (3-8 months) (N = 37) | 5.7 (1.7) | NA | |
| Late (≥ 9 months) (N = 15) | 14.3 (6) | NA | |
| . | Chronic GVHD(n = 52) . | No GVHD (controls)(n = 28) . | P . |
|---|---|---|---|
| Mean age, y (SD) | 11.5 (5.5) | 9.4 (6.3) | .14 |
| Sex | |||
| Male | 34 (65%) | 17 (61%) | .81 |
| Female | 18 (35%) | 11 (39%) | |
| Donor source | |||
| Bone marrow | 24 (46%) | 17 (61%) | .28 |
| Peripheral blood | 18 (35%) | 5 (18%) | |
| Umbilical cord blood | 10 (19%) | 6 (21%) | |
| Donor type | |||
| Related donor | 22 (43%) | 20 (71%) | .02 |
| Unrelated donor | 29 (57%) | 8 (29%) | |
| Acute GVHD | |||
| Yes | 33 (65%) | 12 (43%) | .10 |
| No | 18 (35%) | 16 (57%) | |
| cGVHD onset time (mean, SD) | |||
| Early (3-8 months) (N = 37) | 5.7 (1.7) | NA | |
| Late (≥ 9 months) (N = 15) | 14.3 (6) | NA | |
The number of cGVHD patients presented represents those that had evaluable samples at diagnosis and control patients who had evaluable samples submitted at 6 or 12 months after transplantation.