Pharmacokinetics after the fourth dose
| Dose, mg . | No. . | Cmax, mg/mL . | T1/2, h . | CL, mL/h per kg . | AUC0-inf, h*mg/mL . |
|---|---|---|---|---|---|
| 300 | 10 | 129 (112-161) | 447 (293-711) | 9 (1-17) | 74 616 (41 286-282 593) |
| 500 | 9 | 185 (84-373) | 303 (57-632) | 16 (4-78) | 53 261 (6957-203 068) |
| 700 | 9 | 355 (263-560) | 322 (189-625) | 10 (6-23) | 185 251 (51 925-380 185) |
| 1000 | 10 | 610 (362-857) | 567 (77-720) | 3 (1-29) | 644 080 (47 188-1 107 841) |
| Dose, mg . | No. . | Cmax, mg/mL . | T1/2, h . | CL, mL/h per kg . | AUC0-inf, h*mg/mL . |
|---|---|---|---|---|---|
| 300 | 10 | 129 (112-161) | 447 (293-711) | 9 (1-17) | 74 616 (41 286-282 593) |
| 500 | 9 | 185 (84-373) | 303 (57-632) | 16 (4-78) | 53 261 (6957-203 068) |
| 700 | 9 | 355 (263-560) | 322 (189-625) | 10 (6-23) | 185 251 (51 925-380 185) |
| 1000 | 10 | 610 (362-857) | 567 (77-720) | 3 (1-29) | 644 080 (47 188-1 107 841) |
Results are shown as median values (range).