MiRNAs down-regulated in 122 newly diagnosed AML patients with respect to CD34+ cells obtained from 10 healthy donors
| MicroRNA . | SAM score* . | Fold change . | FDR, %† . |
|---|---|---|---|
| hsa-miR-126 | −3.28 | 0.21 | 0 |
| hsa-miR-130a | −2.91 | 0.29 | 0 |
| hsa-miR-135 | −2.55 | 0.38 | 0 |
| hsa-miR-93 | −2.52 | 0.08 | 0 |
| hsa-miR-146 | −2.47 | 0.41 | 0 |
| hsa-miR-106b | −2.43 | 0.36 | 0 |
| hsa-miR-224 | −2.39 | 0.32 | 0 |
| hsa-miR-125a | −2.18 | 0.52 | 0 |
| hsa-miR-92 | −2.13 | 0.46 | 0 |
| hsa-miR-106a | −2.12 | 0.46 | 0 |
| hsa-miR-95 | −2.07 | 0.04 | 0 |
| hsa-miR-155 | −2.03 | 0.49 | 0 |
| hsa-miR-25 | −2.01 | 0.51 | 0 |
| hsa-miR-96 | −1.94 | 0.25 | 0 |
| hsa-miR-124a | −1.92 | 0.37 | 0 |
| hsa-miR-18 | −1.89 | 0.38 | 0 |
| hsa-miR-20 | −1.87 | 0.51 | 0 |
| hsa-let-7d | −1.81 | 0.48 | 0 |
| hsa-miR-26a | −1.76 | 0.48 | 0 |
| hsa-miR-222 | −1.71 | 0.51 | 0 |
| hsa-miR-101 | −1.67 | 0.51 | 0 |
| hsa-miR-338 | −1.54 | 0.31 | 0 |
| hsa-miR-371 | −1.51 | 0.38 | 0 |
| hsa-miR-199b | −1.44 | 0.03 | 0 |
| hsa-miR-29b | −1.41 | 0.12 | 0 |
| hsa-miR-301 | −1.37 | 0.47 | 0 |
| MicroRNA . | SAM score* . | Fold change . | FDR, %† . |
|---|---|---|---|
| hsa-miR-126 | −3.28 | 0.21 | 0 |
| hsa-miR-130a | −2.91 | 0.29 | 0 |
| hsa-miR-135 | −2.55 | 0.38 | 0 |
| hsa-miR-93 | −2.52 | 0.08 | 0 |
| hsa-miR-146 | −2.47 | 0.41 | 0 |
| hsa-miR-106b | −2.43 | 0.36 | 0 |
| hsa-miR-224 | −2.39 | 0.32 | 0 |
| hsa-miR-125a | −2.18 | 0.52 | 0 |
| hsa-miR-92 | −2.13 | 0.46 | 0 |
| hsa-miR-106a | −2.12 | 0.46 | 0 |
| hsa-miR-95 | −2.07 | 0.04 | 0 |
| hsa-miR-155 | −2.03 | 0.49 | 0 |
| hsa-miR-25 | −2.01 | 0.51 | 0 |
| hsa-miR-96 | −1.94 | 0.25 | 0 |
| hsa-miR-124a | −1.92 | 0.37 | 0 |
| hsa-miR-18 | −1.89 | 0.38 | 0 |
| hsa-miR-20 | −1.87 | 0.51 | 0 |
| hsa-let-7d | −1.81 | 0.48 | 0 |
| hsa-miR-26a | −1.76 | 0.48 | 0 |
| hsa-miR-222 | −1.71 | 0.51 | 0 |
| hsa-miR-101 | −1.67 | 0.51 | 0 |
| hsa-miR-338 | −1.54 | 0.31 | 0 |
| hsa-miR-371 | −1.51 | 0.38 | 0 |
| hsa-miR-199b | −1.44 | 0.03 | 0 |
| hsa-miR-29b | −1.41 | 0.12 | 0 |
| hsa-miR-301 | −1.37 | 0.47 | 0 |
SAM identifies genes with statistically significant changes in expression by assimilating a set of gene-specific scores (ie, paired t tests). Each gene is assigned a score on the basis of its change in gene expression relative to the standard deviation of repeated measurements for that gene. Genes with scores greater than a threshold are deemed potentially significant.
The percentage of such genes identified by chance is the q value or false discovery rate.