Table 5 MDS, CMD, and CMML patient... | American Society of Hematology

Table 5

MDS, CMD, and CMML patient counts and rates by subtype for both sexes, 2001-2003

Disease type according to ICD-O-3	ICD-O-3 morphology code	Rate†	SEER			NAACCR – SEER*			Total
Disease type according to ICD-O-3	ICD-O-3 morphology code	Rate†	Count	%	Rate†	Count	%	Rate†	Count	%
Total‡	—	5.43	11 311	—	5.40	29 637	—	5.40	40 948	—
MDS	998	3.42	7 076	100.0	3.22	17 722	100.0	3.28	24 798	100.0
RA	9980	0.57	1 186	16.8	0.43	2 375	13.4	0.47	3 561	14.4
RA with sideroblasts	9982	0.40	819	11.6	0.30	1 662	9.4	0.33	2 481	10.0
RA with excess blasts	9983	0.47	968	13.7	0.34	1 850	10.4	0.37	2 818	11.4
RA with excess blasts in transformation	9984	0.06	129	1.8	0.05	257	1.5	0.05	386	1.6
Refractory cytopenia with multilineage dysplasia	9985	0.13	262	3.7	0.06	342	1.9	0.08	604	2.4
MDS with 5q deletion	9986	0.06	119	1.7	0.06	311	1.8	0.06	430	1.7
Therapy-related MDS	9987	0.06	126	1.8	0.09	484	2.7	0.08	610	2.5
MDS, not otherwise specified (NOS)	9989	1.67	3 467	49.0	1.89	10 441	58.9	1.84	13 908	56.1
CMD§	995-996	2.01	4 226	100.0	2.17	11 893	100.0	2.13	16 119	100.0
Polycythemia vera	9950	0.79	1 679	39.7	1.01	5 504	46.3	0.95	7 183	44.6
Myelosclerosis with myeloid metaplasia∥	9961	0.25	514	12.2	0.21	1 160	9.8	0.22	1 674	10.4
Essential thrombocythemia	9962	0.53	1 108	26.2	0.51	2 766	23.3	0.51	3 874	24.0
Chronic neutrophilic leukemia	9963	0.01	10	0.2	0.01	32	0.3	0.01	42	0.3
Hypereosinophilic syndrome	9964	0.03	71	1.7	0.03	158	1.3	0.03	229	1.4
Chronic myeloproliferative disease, NOS	9960	0.41	844	20.0	0.41	2 273	19.1	0.41	3 117	19.3
Chronic myelomonocytic leukemia (CMML), NOS¶	9945	0.37	751		0.34	1 850		0.34	2 601

Disease type according to ICD-O-3	ICD-O-3 morphology code	Rate†	SEER			NAACCR – SEER*			Total
Disease type according to ICD-O-3	ICD-O-3 morphology code	Rate†	Count	%	Rate†	Count	%	Rate†	Count	%
Total‡	—	5.43	11 311	—	5.40	29 637	—	5.40	40 948	—
MDS	998	3.42	7 076	100.0	3.22	17 722	100.0	3.28	24 798	100.0
RA	9980	0.57	1 186	16.8	0.43	2 375	13.4	0.47	3 561	14.4
RA with sideroblasts	9982	0.40	819	11.6	0.30	1 662	9.4	0.33	2 481	10.0
RA with excess blasts	9983	0.47	968	13.7	0.34	1 850	10.4	0.37	2 818	11.4
RA with excess blasts in transformation	9984	0.06	129	1.8	0.05	257	1.5	0.05	386	1.6
Refractory cytopenia with multilineage dysplasia	9985	0.13	262	3.7	0.06	342	1.9	0.08	604	2.4
MDS with 5q deletion	9986	0.06	119	1.7	0.06	311	1.8	0.06	430	1.7
Therapy-related MDS	9987	0.06	126	1.8	0.09	484	2.7	0.08	610	2.5
MDS, not otherwise specified (NOS)	9989	1.67	3 467	49.0	1.89	10 441	58.9	1.84	13 908	56.1
CMD§	995-996	2.01	4 226	100.0	2.17	11 893	100.0	2.13	16 119	100.0
Polycythemia vera	9950	0.79	1 679	39.7	1.01	5 504	46.3	0.95	7 183	44.6
Myelosclerosis with myeloid metaplasia∥	9961	0.25	514	12.2	0.21	1 160	9.8	0.22	1 674	10.4
Essential thrombocythemia	9962	0.53	1 108	26.2	0.51	2 766	23.3	0.51	3 874	24.0
Chronic neutrophilic leukemia	9963	0.01	10	0.2	0.01	32	0.3	0.01	42	0.3
Hypereosinophilic syndrome	9964	0.03	71	1.7	0.03	158	1.3	0.03	229	1.4
Chronic myeloproliferative disease, NOS	9960	0.41	844	20.0	0.41	2 273	19.1	0.41	3 117	19.3
Chronic myelomonocytic leukemia (CMML), NOS¶	9945	0.37	751		0.34	1 850		0.34	2 601

Data source: NAACCR's CINA December 2005 submission of 1995 to 2003 patients.

NAACCR registries minus SEER registries; excludes Seattle from Washington, Detroit from Michigan, and Atlanta from Georgia.

Rate per 100 000; age-adjusted based on 2000 US standard population.

Includes 9 and 22 patients with other malignant hematologic disorders (ICD-O-3 code 9970-9975) in SEER and NAACCR minus SEER, respectively.

Synonymous with myeloproliferative neoplasms; does not include BCR/ABL⁺ chronic myelocytic leukemia.

Synonymous with chronic idiopathic myelofibrosis (WHO classification) or primary myelofibrosis.

CMML is considered MDS in the FAB classification, but it is grouped with the leukemias in the WHO classification and ICD-O-3.