Patient characteristics
| . | All patientswith bleeding, cases . | All patients without bleeding, controls . | AF patients with bleeding, cases . | AF patients without bleeding, controls . | VTE patients with bleeding, cases . | VTE patients without bleeding, controls . | ACS patients with bleeding, cases . | ACS patients without bleeding, controls . |
|---|---|---|---|---|---|---|---|---|
| n | 993 | 993 | 638 | 648 | 141 | 147 | 214 | 198 |
| Age, y | 66.8 | 67.0 | 68.4 | 68.8 | 59.4 | 59.9 | 67.0 | 66.3 |
| Male sex, % | 56.6 | 56.5 | 56.5 | 58.2 | 45.4 | 42.9 | 64.5 | 61.1 |
| Duration of anticoagulation, y | 3.2 | 3.0 | 3.7 | 3.5 | 1.9 | 2.2 | 2.5 | 2.2 |
| Localization of bleeding (%) | ||||||||
| Upper GI | 311 (31.1) | NA | 195 (30.6) | NA | 31 (22.0) | NA | 85 (39.7) | NA |
| Lower GI | 285 (28.7) | NA | 190 (29.8) | NA | 49 (34.8) | NA | 46 (21.5) | NA |
| Intracranial | 151 (15.2) | NA | 96 (15.0) | NA | 11 (7.8) | NA | 44 (20.6) | NA |
| Urogenital | 153 (15.4) | NA | 100 (15.7) | NA | 28 (19.9) | NA | 25 (11.7) | NA |
| Retro/muscle/joint | 64 (6.4) | NA | 39 (6.1) | NA | 15 (10.6) | NA | 10 (4.7) | NA |
| Other | 29 (2.9) | NA | 18 (2.8) | NA | 7 (5.0) | NA | 4 (1.9) | NA |
| . | All patientswith bleeding, cases . | All patients without bleeding, controls . | AF patients with bleeding, cases . | AF patients without bleeding, controls . | VTE patients with bleeding, cases . | VTE patients without bleeding, controls . | ACS patients with bleeding, cases . | ACS patients without bleeding, controls . |
|---|---|---|---|---|---|---|---|---|
| n | 993 | 993 | 638 | 648 | 141 | 147 | 214 | 198 |
| Age, y | 66.8 | 67.0 | 68.4 | 68.8 | 59.4 | 59.9 | 67.0 | 66.3 |
| Male sex, % | 56.6 | 56.5 | 56.5 | 58.2 | 45.4 | 42.9 | 64.5 | 61.1 |
| Duration of anticoagulation, y | 3.2 | 3.0 | 3.7 | 3.5 | 1.9 | 2.2 | 2.5 | 2.2 |
| Localization of bleeding (%) | ||||||||
| Upper GI | 311 (31.1) | NA | 195 (30.6) | NA | 31 (22.0) | NA | 85 (39.7) | NA |
| Lower GI | 285 (28.7) | NA | 190 (29.8) | NA | 49 (34.8) | NA | 46 (21.5) | NA |
| Intracranial | 151 (15.2) | NA | 96 (15.0) | NA | 11 (7.8) | NA | 44 (20.6) | NA |
| Urogenital | 153 (15.4) | NA | 100 (15.7) | NA | 28 (19.9) | NA | 25 (11.7) | NA |
| Retro/muscle/joint | 64 (6.4) | NA | 39 (6.1) | NA | 15 (10.6) | NA | 10 (4.7) | NA |
| Other | 29 (2.9) | NA | 18 (2.8) | NA | 7 (5.0) | NA | 4 (1.9) | NA |
GI indicates gastrointestinal; retro, retroperitoneal; and NA, not applicable.