NHLBI-sponsored clinical trials that involve hydroxyurea treatment for children and adolescents with sickle cell disease, as of January 2010
| Protocol . | www.ClinicalTrials.gov NCT . | Description . | Enrollment . | Treatment . |
|---|---|---|---|---|
| BABY HUG | 00006400 | Phase 3 | Completed | Completed |
| Hydroxyurea versus placebo | ||||
| HbSS, age 9-18 mo | ||||
| SWiTCH | 00122980 | Phase 3 | Completed | Ongoing |
| Hydroxyurea/phlebotomy versus transfusion/chelation | ||||
| HbSS, age 5-19 y with previous stroke and iron overload | ||||
| HUSTLE | 00305175 | Observational longitudinal | Recruiting | Ongoing |
| Open-label hydroxyurea therapy | ||||
| HbSS, age < 30 y | ||||
| CHAMPS | 00532883 | Phase 3 | Terminated | Completed |
| Hydroxyurea and magnesium pidolate versus placebo | ||||
| HbSC, all ages | ||||
| TWiTCH | Pending | Phase 3 | Not yet opened | Not yet opened |
| Hydroxyurea versus transfusion | ||||
| HbSS, age 4-16 y |
| Protocol . | www.ClinicalTrials.gov NCT . | Description . | Enrollment . | Treatment . |
|---|---|---|---|---|
| BABY HUG | 00006400 | Phase 3 | Completed | Completed |
| Hydroxyurea versus placebo | ||||
| HbSS, age 9-18 mo | ||||
| SWiTCH | 00122980 | Phase 3 | Completed | Ongoing |
| Hydroxyurea/phlebotomy versus transfusion/chelation | ||||
| HbSS, age 5-19 y with previous stroke and iron overload | ||||
| HUSTLE | 00305175 | Observational longitudinal | Recruiting | Ongoing |
| Open-label hydroxyurea therapy | ||||
| HbSS, age < 30 y | ||||
| CHAMPS | 00532883 | Phase 3 | Terminated | Completed |
| Hydroxyurea and magnesium pidolate versus placebo | ||||
| HbSC, all ages | ||||
| TWiTCH | Pending | Phase 3 | Not yet opened | Not yet opened |
| Hydroxyurea versus transfusion | ||||
| HbSS, age 4-16 y |
NHLBI indicates National Heart, Lung, and Blood Institute.