Tyrosine kinase inhibitors and other agents targeting Bcr-Abl
| TK inhibitors . |
|---|
| Original TK inhibitor: Imatinib mesylate |
| Second-generation TK inhibitors: Dasatinib, nilotinib, bosutinib (SKI-606) |
| Aurora kinase inhibitor active against the T315I mutation: MK-0457 |
| Other TK inhibitors in development: INNO-406, SGX70393 |
| Agents with miscellaneous modes of action: IPI-504, GNF-2 |
| TK inhibitors . |
|---|
| Original TK inhibitor: Imatinib mesylate |
| Second-generation TK inhibitors: Dasatinib, nilotinib, bosutinib (SKI-606) |
| Aurora kinase inhibitor active against the T315I mutation: MK-0457 |
| Other TK inhibitors in development: INNO-406, SGX70393 |
| Agents with miscellaneous modes of action: IPI-504, GNF-2 |