The complete cytogenetic response (CCyR) and partial cytogenetic re-sponse (PCyR) rates may be combined and referred to as a major cytogenetic response (MCyR) rate. A major molecular response (MMR) is equivalent to a 3-log reduction from a standardized baseline value of 100%. The terms “transcripts not detected” and “transcripts not detectable” are preferred to “complete molecular response” (sometimes referred to as CMR). There is no current agreement as to whether RQ-PCR technology is as sensitive as nested PCR and thus whether the finding of undetectable transcripts by RQ-PCR needs to be confirmed with nested PCR.