Clinical and laboratory data at diagnosis in patients with BCL2-938C>A gene polymorphism
| Variable . | All patients . | BCL2-938 AA genotype . | BCL2-938 AC genotype . | BCL2-938 CC genotype . | P . |
|---|---|---|---|---|---|
| No. of patients | 123 | 42 | 55 | 26 | |
| Median age at diagnosis, y | 60 | 61 | 58 | 61 | NS |
| Male, no. (%)* | 86 (70) | 28 (67) | 42 (76) | 16 (61) | NS |
| Binet stage at diagnosis, no. (%); n = 114 | NS | ||||
| A | 80 (70) | 20 (54) | 39 (75) | 21 (84) | |
| B | 25 (22) | 13 (35) | 9 (17) | 3 (12) | |
| C | 9 (8) | 4 (11) | 4 (8) | 1 (4) | |
| CD38+ leukemia, no. (%); n = 123 | 46 (37) | 18 (43) | 18 (33) | 10 (38) | NS |
| ZAP-70+ leukemia, no. (%); n = 113 | 52 (46) | 21 (55) | 21 (41) | 10 (42) | NS |
| Thymidine kinase, IU/L; n = 72† | 19.0 ± 26.7 | 21.5 ± 30.7 | 21.0 ± 28.6 | 10.6 ± 9.5 | NS |
| Genomic aberrations, no. (%); n = 103 | NS | ||||
| Deletion 11 | 10 (10) | 4 (11) | 5 (10) | 1 (6) | |
| Deletion 17 | 6 (6) | 2 (6) | 3 (6) | 1 (6) | |
| Trisomy 12 | 11 (11) | 6 (17) | 4 (8) | 1 (6) | |
| Normal | 19 (18) | 5 (14) | 9 (18) | 5 (28) | |
| Deletion 13 | 57 (55) | 18 (51) | 29 (58) | 10 (56) | |
| Received therapy, no. (%) | 56 (46) | 26 (62) | 21 (55) | 9 (35) | .03 |
| Variable . | All patients . | BCL2-938 AA genotype . | BCL2-938 AC genotype . | BCL2-938 CC genotype . | P . |
|---|---|---|---|---|---|
| No. of patients | 123 | 42 | 55 | 26 | |
| Median age at diagnosis, y | 60 | 61 | 58 | 61 | NS |
| Male, no. (%)* | 86 (70) | 28 (67) | 42 (76) | 16 (61) | NS |
| Binet stage at diagnosis, no. (%); n = 114 | NS | ||||
| A | 80 (70) | 20 (54) | 39 (75) | 21 (84) | |
| B | 25 (22) | 13 (35) | 9 (17) | 3 (12) | |
| C | 9 (8) | 4 (11) | 4 (8) | 1 (4) | |
| CD38+ leukemia, no. (%); n = 123 | 46 (37) | 18 (43) | 18 (33) | 10 (38) | NS |
| ZAP-70+ leukemia, no. (%); n = 113 | 52 (46) | 21 (55) | 21 (41) | 10 (42) | NS |
| Thymidine kinase, IU/L; n = 72† | 19.0 ± 26.7 | 21.5 ± 30.7 | 21.0 ± 28.6 | 10.6 ± 9.5 | NS |
| Genomic aberrations, no. (%); n = 103 | NS | ||||
| Deletion 11 | 10 (10) | 4 (11) | 5 (10) | 1 (6) | |
| Deletion 17 | 6 (6) | 2 (6) | 3 (6) | 1 (6) | |
| Trisomy 12 | 11 (11) | 6 (17) | 4 (8) | 1 (6) | |
| Normal | 19 (18) | 5 (14) | 9 (18) | 5 (28) | |
| Deletion 13 | 57 (55) | 18 (51) | 29 (58) | 10 (56) | |
| Received therapy, no. (%) | 56 (46) | 26 (62) | 21 (55) | 9 (35) | .03 |