LBH589 causes loss of viability of primary Ph− ALL cells
| Patient sample . | Loss of cell viability, % . | |
|---|---|---|
| LBH589, 5 nM . | LBH589, 50 nM . | |
| 1 | 52.9 | 65.3 |
| 2 | 73.9 | 75.6 |
| 3 | 74.1 | 82.6 |
| 4* | 33.5 | 57.8 |
| 5 | 27.6 | 52.6 |
| 6 | 12.1 | 53.9 |
| Patient sample . | Loss of cell viability, % . | |
|---|---|---|
| LBH589, 5 nM . | LBH589, 50 nM . | |
| 1 | 52.9 | 65.3 |
| 2 | 73.9 | 75.6 |
| 3 | 74.1 | 82.6 |
| 4* | 33.5 | 57.8 |
| 5 | 27.6 | 52.6 |
| 6 | 12.1 | 53.9 |
Samples of primary Ph− ALL cells were treated in culture with the indicated concentrations of LBH589 for 48 hours. The percentage of nonviable cells was determined by annexin V/PI staining and flow cytometry. The values represent the percentages of loss of viability normalized to that of the untreated cells and are the means of two separate treatments.
Relapsed patient.