Table 2

Fiber diameter with and without FXIIIa cross-linking (determined by scanning electron microscopy)

Recombinant normal
γK406R
γQ398N/Q399N/K406R
Diameter (± SD), nmnDiameter (± SD), nmnDiameter (± SD), nmn
Non–cross-linked 146 (23) 600 145 (26) 600 167 (28)† 800 
Cross-linked 137 (31)* 800 168 (30)‡ 800 184 (22)‡ 800 
Recombinant normal
γK406R
γQ398N/Q399N/K406R
Diameter (± SD), nmnDiameter (± SD), nmnDiameter (± SD), nmn
Non–cross-linked 146 (23) 600 145 (26) 600 167 (28)† 800 
Cross-linked 137 (31)* 800 168 (30)‡ 800 184 (22)‡ 800 
*

Decrease in fiber diameter after cross-linking (P < .05).

†

Larger fiber diameter compared with non–cross-linked recombinant normal and γK406R fibrinogen (P < .05).

‡

Increase in fiber diameter after cross-linking (P < .05).

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