Summary of the outcome of ENU mutagenesis studies
| Genotype . | Lymphoma . | MPD . | Other* . | Total . |
|---|---|---|---|---|
| 4-wk cohort | ||||
| WT | 4/15 | 2/15 (13) | 2/15 (13) | 8/15 (40) |
| Egr1+/− | 7/15 | 6/15 (40) | 1/15 (7) | 14/15 (93) |
| Egr1−/− | 8/15 | 6/15 (40) | 1/15 (7) | 15/15 (100) |
| 20-wk cohort | ||||
| WT | 1/12 | 0/12 (0) | 2/12 (17) | 3/12 (25) |
| Egr1+/− | 6/12 | 3/12 (25) | 2/12 (17) | 11/12 (92) |
| Egr1−/− | 4/9 | 4/9 (44) | 1/9 (11) | 9/9 (100) |
| Genotype . | Lymphoma . | MPD . | Other* . | Total . |
|---|---|---|---|---|
| 4-wk cohort | ||||
| WT | 4/15 | 2/15 (13) | 2/15 (13) | 8/15 (40) |
| Egr1+/− | 7/15 | 6/15 (40) | 1/15 (7) | 14/15 (93) |
| Egr1−/− | 8/15 | 6/15 (40) | 1/15 (7) | 15/15 (100) |
| 20-wk cohort | ||||
| WT | 1/12 | 0/12 (0) | 2/12 (17) | 3/12 (25) |
| Egr1+/− | 6/12 | 3/12 (25) | 2/12 (17) | 11/12 (92) |
| Egr1−/− | 4/9 | 4/9 (44) | 1/9 (11) | 9/9 (100) |
Numbers (%) of mice are shown for all outcomes.
Several mice were killed due to severe dermatitis or a reactive condition. In other cases, the cause of death was not established, but may include neoplastic diseases. A comparison of the rates of death due to lymphoma, MPD, or other causes revealed significant differences in overall mortality as well as the cause of death in mice across genotypes (4-week cohort, Fisher exact P = .021; 20-week cohort, Fisher exact P = .019; and pooled, Mantel-Haenszel P < .001).