Cytogenetic abnormalities and gene mutations associated with t(8; 21) leukemia
| Mutations . | Frequency, no./total (%) . | References . |
|---|---|---|
| Cytogenetic abnormalities | ||
| −X in female patients | 115/331 (35) | 31,,,,,-37 |
| −Y in male patients | 235/419 (56) | 31,,,,,-37 |
| Del (9q) | 80/454 (18) | 32,36,37 |
| Trisomy 4 | 8/75 (11) | 3 |
| Trisomy 8 | 28/454 (6) | 32,36,37 |
| Others | 77/454 (16) | 32,36,37 |
| Molecular genetic mutations | ||
| FLT3-length mutation: FLT3/ITD | 27/387 (6.9) | 36,38,,-41 |
| FLT3 D853 activating mutations | 5/184 (2.7) | 36,38,41 |
| c-KIT D816 (D>Y, D>V, D>H, D>I) | 43/351 (12.3) | 36,38,42,,-45 |
| c-KIT N822K | 10/54 (19) | 46 |
| NRAS: codons 12,13, 61 | 40/469 (8.5) | 36,38,47,-49 |
| PU.1 | 1/19 (5.3) | 36 |
| AML1 | 1/26 (3.8) | 36 |
| Mutations . | Frequency, no./total (%) . | References . |
|---|---|---|
| Cytogenetic abnormalities | ||
| −X in female patients | 115/331 (35) | 31,,,,,-37 |
| −Y in male patients | 235/419 (56) | 31,,,,,-37 |
| Del (9q) | 80/454 (18) | 32,36,37 |
| Trisomy 4 | 8/75 (11) | 3 |
| Trisomy 8 | 28/454 (6) | 32,36,37 |
| Others | 77/454 (16) | 32,36,37 |
| Molecular genetic mutations | ||
| FLT3-length mutation: FLT3/ITD | 27/387 (6.9) | 36,38,,-41 |
| FLT3 D853 activating mutations | 5/184 (2.7) | 36,38,41 |
| c-KIT D816 (D>Y, D>V, D>H, D>I) | 43/351 (12.3) | 36,38,42,,-45 |
| c-KIT N822K | 10/54 (19) | 46 |
| NRAS: codons 12,13, 61 | 40/469 (8.5) | 36,38,47,-49 |
| PU.1 | 1/19 (5.3) | 36 |
| AML1 | 1/26 (3.8) | 36 |