Clinical features by cytogenetic subgroup of patients with Philadelphia-negative adult acute lymphoblastic leukemia on MRC UKALLXII/ECOG 2993
| Cytogenetic subgroup* . | No. of cases (%) . | Male cases, %† . | Mean age, y‡ . | Mean WCC, × 109/L‡ . | T-cell cases, %† . |
|---|---|---|---|---|---|
| Total§ | 782 (100) | 62 | 31 | 53 | 22 |
| t(4;11)(q21;q23) | 54 (7) | 33‖ | 38‖ | 234‖ | 0¶ |
| Other MLL/11q23 translocations | 15 (2) | 67 | 34 | 128‖ | 40 |
| t(1;19)(q21;p13.3) | 24 (3) | 58 | 31 | 46 | 0‖ |
| t(8;14)(q24.1;q32) | 16 (2) | 69 | 39‖ | 33 | 0‖ |
| t(10;14)(q24;q11.2) | 16 (2) | 63 | 35 | 65 | 100¶ |
| Other TCR translocations | 18 (2) | 89¶ | 27 | 97‖ | 100¶ |
| 14q32 translocations | 45 (6) | 58 | 33 | 50 | 12 |
| del(6q) | 55 (7) | 64 | 28‖ | 63‖ | 35‖ |
| del(7p) | 23 (3) | 70 | 30 | 49 | 17 |
| −7# | 19 (2) | 68 | 41‖ | 12‖ | 22 |
| +8# | 23 (3) | 57 | 30 | 44 | 25 |
| +X# | 34 (4) | 56 | 35¶ | 70¶ | 3‖ |
| del(9p) | 71 (9) | 65 | 29¶ | 37 | 16 |
| abnormality of 11q | 29 (4) | 72 | 33 | 70 | 34 |
| del(12p) | 29 (4) | 62 | 30 | 38 | 19 |
| del(13q)/−13 | 40 (5) | 63 | 30 | 46 | 19 |
| del(17p) | 40 (5) | 58 | 31 | 33 | 10 |
| Complex karyotype | 41 (5) | 73 | 33 | 40 | 25 |
| Low hypodiploidy/near triploidy | 31 (4) | 52 | 34 | 17‖ | 3¶ |
| High hyperdiploidy | 77 (10) | 60 | 27‖ | 15‖ | 4¶ |
| Tetraploidy | 15 (2) | 67 | 33 | 11¶ | 20 |
| Other abnormality** | 102 (13) | 72¶ | 30 | 45 | 24 |
| Normal karyotype | 195 (25) | 62 | 31 | 34‖ | 23 |
| Cytogenetic subgroup* . | No. of cases (%) . | Male cases, %† . | Mean age, y‡ . | Mean WCC, × 109/L‡ . | T-cell cases, %† . |
|---|---|---|---|---|---|
| Total§ | 782 (100) | 62 | 31 | 53 | 22 |
| t(4;11)(q21;q23) | 54 (7) | 33‖ | 38‖ | 234‖ | 0¶ |
| Other MLL/11q23 translocations | 15 (2) | 67 | 34 | 128‖ | 40 |
| t(1;19)(q21;p13.3) | 24 (3) | 58 | 31 | 46 | 0‖ |
| t(8;14)(q24.1;q32) | 16 (2) | 69 | 39‖ | 33 | 0‖ |
| t(10;14)(q24;q11.2) | 16 (2) | 63 | 35 | 65 | 100¶ |
| Other TCR translocations | 18 (2) | 89¶ | 27 | 97‖ | 100¶ |
| 14q32 translocations | 45 (6) | 58 | 33 | 50 | 12 |
| del(6q) | 55 (7) | 64 | 28‖ | 63‖ | 35‖ |
| del(7p) | 23 (3) | 70 | 30 | 49 | 17 |
| −7# | 19 (2) | 68 | 41‖ | 12‖ | 22 |
| +8# | 23 (3) | 57 | 30 | 44 | 25 |
| +X# | 34 (4) | 56 | 35¶ | 70¶ | 3‖ |
| del(9p) | 71 (9) | 65 | 29¶ | 37 | 16 |
| abnormality of 11q | 29 (4) | 72 | 33 | 70 | 34 |
| del(12p) | 29 (4) | 62 | 30 | 38 | 19 |
| del(13q)/−13 | 40 (5) | 63 | 30 | 46 | 19 |
| del(17p) | 40 (5) | 58 | 31 | 33 | 10 |
| Complex karyotype | 41 (5) | 73 | 33 | 40 | 25 |
| Low hypodiploidy/near triploidy | 31 (4) | 52 | 34 | 17‖ | 3¶ |
| High hyperdiploidy | 77 (10) | 60 | 27‖ | 15‖ | 4¶ |
| Tetraploidy | 15 (2) | 67 | 33 | 11¶ | 20 |
| Other abnormality** | 102 (13) | 72¶ | 30 | 45 | 24 |
| Normal karyotype | 195 (25) | 62 | 31 | 34‖ | 23 |
See “Patients, materials, and methods” for a full definition of the individual cytogenetic subgroups.
The percentage of male and T-cell cases were compared with all other Philadelphia-negative cases with a cytogenetic result using a chi-square test.
The age (y) and log(WCC + 1) of patients was compared with all other Philadelphia-negative cases with a cytogenetic result using a t test.
Philadelphia-negative cases with a successful cytogenetic result.
P < .05.
P < .01.
These groups exclude cases with low hypodiploid/near triploidy, high hyperdiploidy, and tetraploidy.
Abnormal karyotypes excluding those with any of the above abnormalities.