Mutation analysis of PAX5, RhoH/TTF, cMYC, and PIM1 in extranodal DLBCL and MALT lymphoma
| . | PAX5 . | RhoH/TTF . | cMYC . | PIM1 . | IgH gene . | IgH mutations . |
|---|---|---|---|---|---|---|
| DLBCL | ||||||
| GHM1 | 799 C>T | 707 A>G | 3341 G>A | 1147 T>C | NA | NA |
| 810 C>T | 3377 A>T | 1157 T>C | ||||
| 1831 C>T | ||||||
| GHM2 | — | — | 3384 G>A | — | 1-69 | 7.62 |
| 3539 C>A | ||||||
| 5045 C>T | ||||||
| GHM3 | 819 G>A | — | 5021 C>T | — | 3-23 | 0 |
| 827 T>A | ||||||
| GHM4 | 1362 G>A | — | 5009 C>T | — | NA | NA |
| 5026 G>T* | ||||||
| 5044 G>T* | ||||||
| GHM5 | — | 755 A>G | 4568 C>T | — | 3-30-3 | 6.45 |
| GHM6 | 789 C>T | 764 A>T | 3613 A>G | 1355 C>A | NA | NA |
| 841 G>A | 1409 C>T* | |||||
| GHM7 | 718 C>T | — | 4638 C>T | 2041 G>A* | 4-34 | 2.98 |
| 2079 C>T | ||||||
| GHM8 | 890 G>A | 452 A>C | — | — | 3-30 | 4.04 |
| GHM9 | — | — | — | 1285 G>A | NA | NA |
| 1292 G>A | ||||||
| GHM10 | 1264 G>A | 755 A>G | — | — | NA | NA |
| EHM11 | — | — | 3472 T>C | 1905 G>T* | NA | NA |
| 5012 C>T | ||||||
| 5041 C>T* | ||||||
| EHM12 | 733 C>T | — | — | 1465 C>A* | 6-1 | 2.97 |
| 735 G>A | 1849 G>C* | |||||
| EHM15 | 1142 C>T | 329 C>T | 3522 A>G | 1747 G>A* | 3-30-3 | 8.16 |
| 1149 G>C | 4969 C>T* | 1749 G>A | ||||
| 1271 G>A | 4972 C>T* | |||||
| EHM16 | — | 443 C>T | 2577 C>T* | 1610 C>T* | 3-30-3 | 2.4 |
| 850 C>G | 2859 T>C* | |||||
| 4747 C>A* | ||||||
| EHM17 | — | — | 2746 C>T* | 1165 G>A | NA | NA |
| 4512 C>T | 1364 C>A | |||||
| EHM18 | 904 G>A | — | 3561 C>T | 1162 G>T | 2-70 | 2.12 |
| 1755 G>A | ||||||
| 1769 G>A* | ||||||
| EHM19 | — | 640 G>A | 4606 A>G* | 1998 ins G | 1-69 | 4.21 |
| 700 G>A | ||||||
| MALT | ||||||
| ENM14 | 1148 G>A | — | 2601 G>A* | — | 3-30-3 | 6.06 |
| 1150 G>T | 2640 G>A* | |||||
| ENM20 | 813 G>A | 486 T>G | 2821 C>G* | — | NA | NA |
| 1324 A>G | ||||||
| ENM21 | — | — | 3207 C>A | — | 1-69 | 5.52 |
| ENM29 | — | — | — | 1637 T>C | 1-69 | 0 |
| 1987 G>T* | ||||||
| ENM30 | — | — | — | 1802 A>G* | 4-34 | 0 |
| ENM33 | — | — | 2792 C>T | — | 1-69 | 2.17 |
| ENM35 | — | 649 C>T | 5042 C>T | 1148 G>T | 4-34 | 2.4 |
| GNM36 | — | — | 2494 G>A* | 1863 T>A* | 5-51 | 0 |
| GNM37 | 1366 G>A | — | — | 1123 G>C | 4-34 | 0 |
| GNM38 | — | — | 3388 C>T | — | 6-1 | 0 |
| GNM39 | — | — | 4700 C>G | 1598 A>T* | 5-51 | 0 |
| 4961 G>C* | ||||||
| GNM40 | — | — | 4618 A>C* | 1441 C>A | NA | NA |
| GNM41 | — | — | 2402 G>C* | 1463 G>A* | 4-34 | 0 |
| . | PAX5 . | RhoH/TTF . | cMYC . | PIM1 . | IgH gene . | IgH mutations . |
|---|---|---|---|---|---|---|
| DLBCL | ||||||
| GHM1 | 799 C>T | 707 A>G | 3341 G>A | 1147 T>C | NA | NA |
| 810 C>T | 3377 A>T | 1157 T>C | ||||
| 1831 C>T | ||||||
| GHM2 | — | — | 3384 G>A | — | 1-69 | 7.62 |
| 3539 C>A | ||||||
| 5045 C>T | ||||||
| GHM3 | 819 G>A | — | 5021 C>T | — | 3-23 | 0 |
| 827 T>A | ||||||
| GHM4 | 1362 G>A | — | 5009 C>T | — | NA | NA |
| 5026 G>T* | ||||||
| 5044 G>T* | ||||||
| GHM5 | — | 755 A>G | 4568 C>T | — | 3-30-3 | 6.45 |
| GHM6 | 789 C>T | 764 A>T | 3613 A>G | 1355 C>A | NA | NA |
| 841 G>A | 1409 C>T* | |||||
| GHM7 | 718 C>T | — | 4638 C>T | 2041 G>A* | 4-34 | 2.98 |
| 2079 C>T | ||||||
| GHM8 | 890 G>A | 452 A>C | — | — | 3-30 | 4.04 |
| GHM9 | — | — | — | 1285 G>A | NA | NA |
| 1292 G>A | ||||||
| GHM10 | 1264 G>A | 755 A>G | — | — | NA | NA |
| EHM11 | — | — | 3472 T>C | 1905 G>T* | NA | NA |
| 5012 C>T | ||||||
| 5041 C>T* | ||||||
| EHM12 | 733 C>T | — | — | 1465 C>A* | 6-1 | 2.97 |
| 735 G>A | 1849 G>C* | |||||
| EHM15 | 1142 C>T | 329 C>T | 3522 A>G | 1747 G>A* | 3-30-3 | 8.16 |
| 1149 G>C | 4969 C>T* | 1749 G>A | ||||
| 1271 G>A | 4972 C>T* | |||||
| EHM16 | — | 443 C>T | 2577 C>T* | 1610 C>T* | 3-30-3 | 2.4 |
| 850 C>G | 2859 T>C* | |||||
| 4747 C>A* | ||||||
| EHM17 | — | — | 2746 C>T* | 1165 G>A | NA | NA |
| 4512 C>T | 1364 C>A | |||||
| EHM18 | 904 G>A | — | 3561 C>T | 1162 G>T | 2-70 | 2.12 |
| 1755 G>A | ||||||
| 1769 G>A* | ||||||
| EHM19 | — | 640 G>A | 4606 A>G* | 1998 ins G | 1-69 | 4.21 |
| 700 G>A | ||||||
| MALT | ||||||
| ENM14 | 1148 G>A | — | 2601 G>A* | — | 3-30-3 | 6.06 |
| 1150 G>T | 2640 G>A* | |||||
| ENM20 | 813 G>A | 486 T>G | 2821 C>G* | — | NA | NA |
| 1324 A>G | ||||||
| ENM21 | — | — | 3207 C>A | — | 1-69 | 5.52 |
| ENM29 | — | — | — | 1637 T>C | 1-69 | 0 |
| 1987 G>T* | ||||||
| ENM30 | — | — | — | 1802 A>G* | 4-34 | 0 |
| ENM33 | — | — | 2792 C>T | — | 1-69 | 2.17 |
| ENM35 | — | 649 C>T | 5042 C>T | 1148 G>T | 4-34 | 2.4 |
| GNM36 | — | — | 2494 G>A* | 1863 T>A* | 5-51 | 0 |
| GNM37 | 1366 G>A | — | — | 1123 G>C | 4-34 | 0 |
| GNM38 | — | — | 3388 C>T | — | 6-1 | 0 |
| GNM39 | — | — | 4700 C>G | 1598 A>T* | 5-51 | 0 |
| 4961 G>C* | ||||||
| GNM40 | — | — | 4618 A>C* | 1441 C>A | NA | NA |
| GNM41 | — | — | 2402 G>C* | 1463 G>A* | 4-34 | 0 |
NA indicates not applicable; and —, not mutated.
Missense mutations.