Table 4.

Multivariate proportional hazards analysis




Event-free survival

Survival

%*
HR
P
HR
P
PR, MS, and MF versus other   37   2.41   < .001   1.98   .004  
Any cytogenetic abnormalities   38   1.60   .014   1.98   .005  
β2-microglobulin level of 339 nM or higher   44   1.47   .061   1.55   .092  
LDH level of 190 μ/L or higher
 
34
 
169
 
.011
 
1.94
 
.009
 



Event-free survival

Survival

%*
HR
P
HR
P
PR, MS, and MF versus other   37   2.41   < .001   1.98   .004  
Any cytogenetic abnormalities   38   1.60   .014   1.98   .005  
β2-microglobulin level of 339 nM or higher   44   1.47   .061   1.55   .092  
LDH level of 190 μ/L or higher
 
34
 
169
 
.011
 
1.94
 
.009
 

n = 255 (of 256 patients); 1 patient is missing cytogenetics. There were 115 progression events and 74 deaths. The following variables were not significant: (1) with the sample of 255, age of 65 years or older was not significant in either analysis (P = .07 for EFS); (2) C-reactive protein level of 4 or higher; and (3) albumin level of 3.5 g/dL or less.

*

This column refers to the percentage of 255 cases having the incidence of each clinic feature specified in the first column of each row.

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