Response definition and monitoring
. | Hematologic response . | Cytogenetic response . | Molecular response (BCR-ABL to control gene ratio according to the international scale) . |
|---|---|---|---|
| Definitions | Complete: Platelet count < 450 × 109/L; WBC count < 10 × 109/L; differential without immature granulocytes and with less than 5% basophils; nonpalpable spleen | Complete: Ph+ 0% Partial: Ph+ 1%-35% Minor: Ph+ 36%-65% Minimal: Ph+ 66%-95% None: Ph+ > 95% | “Complete” indicates transcript nonquantifiable and nondetectable Major: ≤ 0.10 |
| Monitoring | Check every 2 wk until complete response achieved and confirmed, then every 3 mo unless otherwise required | Check at least every 6 mo until complete response achieved and confirmed, hence at least every 12 mo | Check every 3 mo; mutational analysis in case of failure, suboptimal response, or transcript level increase |
. | Hematologic response . | Cytogenetic response . | Molecular response (BCR-ABL to control gene ratio according to the international scale) . |
|---|---|---|---|
| Definitions | Complete: Platelet count < 450 × 109/L; WBC count < 10 × 109/L; differential without immature granulocytes and with less than 5% basophils; nonpalpable spleen | Complete: Ph+ 0% Partial: Ph+ 1%-35% Minor: Ph+ 36%-65% Minimal: Ph+ 66%-95% None: Ph+ > 95% | “Complete” indicates transcript nonquantifiable and nondetectable Major: ≤ 0.10 |
| Monitoring | Check every 2 wk until complete response achieved and confirmed, then every 3 mo unless otherwise required | Check at least every 6 mo until complete response achieved and confirmed, hence at least every 12 mo | Check every 3 mo; mutational analysis in case of failure, suboptimal response, or transcript level increase |
Complete HR, complete CgR, and major MolR should be confirmed on 2 subsequent occasions. CgR is evaluated by morphologic cytogenetics of at least 20 marrow metaphases. FISH of peripheral blood cells should be used only if marrow cells cannot be obtained. MolR is assessed on peripheral blood cells. The international scale for measuring MolR is that proposed by Hughes et al.189