Toxicity summary for all treatment cycles (possibly, probably, definitely related to MS-275)
| Adverse events . | All grades . | Grade 3-4, no. (5, no.) . | |
|---|---|---|---|
| No. of cycles . | % . | ||
| General | |||
| Dehydration, depression, fever, dizziness, insomnia | 5 | 9 | 0 |
| Fatigue | 12 | 21 | 1 |
| Gastrointestinal | |||
| Anorexia | 5 | 9 | 0 |
| Nausea | 8 | 14 | 0 |
| Vomiting | 6 | 10 | 0 |
| Abdominal pain/gas | 1 | 2 | 0 |
| Infections | |||
| Neutropenic bacteremia, sepsis, pneumonia, other | 9 | 16 | 8 (2) |
| Laboratory | |||
| Hypoalbuminemia | 31 | 53 | 0 |
| Hypocalcemia | 32 | 55 | 0 |
| Hyponatremia, hyperkalemia | 2 | 3 | 0 |
| LDH | 1 | 2 | 1 |
| Bilirubin | 1 | 2 | 0 |
| Glucose | 1 | 2 | 1 |
| Triglycerides | 1 | 2 | 1 |
| Hematologic | |||
| Cytopenias | 9 | 16 | 6 |
| Neurologic | |||
| Unsteady gait, lower extremities weakness | 3 | 5 | 1 |
| Somnolence/lethargy | 1 | 2 | 1 |
| Adverse events . | All grades . | Grade 3-4, no. (5, no.) . | |
|---|---|---|---|
| No. of cycles . | % . | ||
| General | |||
| Dehydration, depression, fever, dizziness, insomnia | 5 | 9 | 0 |
| Fatigue | 12 | 21 | 1 |
| Gastrointestinal | |||
| Anorexia | 5 | 9 | 0 |
| Nausea | 8 | 14 | 0 |
| Vomiting | 6 | 10 | 0 |
| Abdominal pain/gas | 1 | 2 | 0 |
| Infections | |||
| Neutropenic bacteremia, sepsis, pneumonia, other | 9 | 16 | 8 (2) |
| Laboratory | |||
| Hypoalbuminemia | 31 | 53 | 0 |
| Hypocalcemia | 32 | 55 | 0 |
| Hyponatremia, hyperkalemia | 2 | 3 | 0 |
| LDH | 1 | 2 | 1 |
| Bilirubin | 1 | 2 | 0 |
| Glucose | 1 | 2 | 1 |
| Triglycerides | 1 | 2 | 1 |
| Hematologic | |||
| Cytopenias | 9 | 16 | 6 |
| Neurologic | |||
| Unsteady gait, lower extremities weakness | 3 | 5 | 1 |
| Somnolence/lethargy | 1 | 2 | 1 |