Table 2 Dose levels Dose level/schedule... | American Society of Hematology

Table 2

Dose levels

Dose level/schedule	No. of patients (no. who completed first cycle)	Total no. of cycles	Median no. of cycles (range)	DLTs
DL 1: 4 mg/m² × 2/4 wk	5 (5)	7	2 (1-4)*	1†
DL 2: 6 mg/m² × 2/4 wk	5 (4)	9*	1	0
DL 3: 8 mg/m² × 2/4 wk	3 (3)	3	1	0
DL 4: 8 mg/m² × 4/6 wk	15 (9)	27	1 (1-5)	0
DL 5: 10 mg/m² × 4/6 wk	10 (5)	12	1 (1-2)	5‡

Dose level/schedule	No. of patients (no. who completed first cycle)	Total no. of cycles	Median no. of cycles (range)	DLTs
DL 1: 4 mg/m² × 2/4 wk	5 (5)	7	2 (1-4)*	1†
DL 2: 6 mg/m² × 2/4 wk	5 (4)	9*	1	0
DL 3: 8 mg/m² × 2/4 wk	3 (3)	3	1	0
DL 4: 8 mg/m² × 4/6 wk	15 (9)	27	1 (1-5)	0
DL 5: 10 mg/m² × 4/6 wk	10 (5)	12	1 (1-2)	5‡

Two patients enrolled at level 1 each received 2 subsequent cycles at level 2.

Fatigue.

Infections (3), neurologic toxicity (1), and abnormal laboratory parameters (1).