Patient characteristics
| Characteristic . | CHOP-21 . | I-CHOP . |
|---|---|---|
| No. of patients | 239 | 238 |
| No. of male patients (%) | 135 (56) | 133 (56) |
| Median age, y (range) | 50 (16-65) | 50 (16-65) |
| 60 y or younger, no. (%) | 210 (88) | 205 (86) |
| Older than 60 y, no. (%) | 29 (12) | 33 (14) |
| Histologic findings according to WHO, no. (%) | ||
| Not reviewed | 35 (15) | 38 (16) |
| Reviewed | 204 (85) | 200 (84) |
| Diffuse large B-cell lymphoma | 126 (62) | 133 (67) |
| Mantle cell lymphoma | 21 (10) | 14 (7) |
| Mediastinal B-cell lymphoma | 1 (0) | 1 (0) |
| Follicular lymphoma, grade 3 | 18 (9) | 15 (8) |
| Follicular lymphoma, grades 1-2 | 14 (7) | 12 (6) |
| Small lymphocytic lymphoma | 1 (0) | 2 (1) |
| Aggressive B-cell lymphoma, unspecified | 5 (2) | 6 (3) |
| Peripheral T-cell lymphoma | 1 (0) | 5 (3) |
| Angioimmunoblastic T-cell lymphoma | 4 (2) | 3 (2) |
| Unclassifiable T-cell | 2 (1) | |
| Anaplastic large cell lymphoma | 11 (5) | 9 (5) |
| WHO performance score, no. (%) | ||
| 0 | 139 (58) | 118 (50) |
| 1 | 83 (35) | 84 (35) |
| 2 | 8 (3) | 22 (9) |
| 3 | 3 (1) | 3 (1) |
| 4 | 1 (0) | 0 (0) |
| Unknown | 5 (2) | 11 (5) |
| LDH level, no. (%) | ||
| Less than 1.5 times ULN | 194 (81) | 206 (87) |
| 1.5 times ULN or more | 45 (19) | 32 (13) |
| LDH level greater than ULN, no. (%) | 111 (46) | 110 (46) |
| Stage, no. (%) | ||
| II | 44 (18) | 32 (13) |
| III | 90 (38) | 78 (33) |
| IV | 105 (44) | 128 (54) |
| B symptoms, no. (%) | 88 (37) | 103 (44) |
| More than 1 extranodal site, no. (%) | 46 (19) | 42 (18) |
| Bulky disease at least 10 cm present, no. (%) | 52 (22) | 51 (21) |
| Age-adjusted IPI score,* no. (%) | ||
| Low-intermediate | 165 (69) | 145 (61) |
| High-intermediate | 69 (29) | 83 (35) |
| High | 5 (2) | 10 (4) |
| Characteristic . | CHOP-21 . | I-CHOP . |
|---|---|---|
| No. of patients | 239 | 238 |
| No. of male patients (%) | 135 (56) | 133 (56) |
| Median age, y (range) | 50 (16-65) | 50 (16-65) |
| 60 y or younger, no. (%) | 210 (88) | 205 (86) |
| Older than 60 y, no. (%) | 29 (12) | 33 (14) |
| Histologic findings according to WHO, no. (%) | ||
| Not reviewed | 35 (15) | 38 (16) |
| Reviewed | 204 (85) | 200 (84) |
| Diffuse large B-cell lymphoma | 126 (62) | 133 (67) |
| Mantle cell lymphoma | 21 (10) | 14 (7) |
| Mediastinal B-cell lymphoma | 1 (0) | 1 (0) |
| Follicular lymphoma, grade 3 | 18 (9) | 15 (8) |
| Follicular lymphoma, grades 1-2 | 14 (7) | 12 (6) |
| Small lymphocytic lymphoma | 1 (0) | 2 (1) |
| Aggressive B-cell lymphoma, unspecified | 5 (2) | 6 (3) |
| Peripheral T-cell lymphoma | 1 (0) | 5 (3) |
| Angioimmunoblastic T-cell lymphoma | 4 (2) | 3 (2) |
| Unclassifiable T-cell | 2 (1) | |
| Anaplastic large cell lymphoma | 11 (5) | 9 (5) |
| WHO performance score, no. (%) | ||
| 0 | 139 (58) | 118 (50) |
| 1 | 83 (35) | 84 (35) |
| 2 | 8 (3) | 22 (9) |
| 3 | 3 (1) | 3 (1) |
| 4 | 1 (0) | 0 (0) |
| Unknown | 5 (2) | 11 (5) |
| LDH level, no. (%) | ||
| Less than 1.5 times ULN | 194 (81) | 206 (87) |
| 1.5 times ULN or more | 45 (19) | 32 (13) |
| LDH level greater than ULN, no. (%) | 111 (46) | 110 (46) |
| Stage, no. (%) | ||
| II | 44 (18) | 32 (13) |
| III | 90 (38) | 78 (33) |
| IV | 105 (44) | 128 (54) |
| B symptoms, no. (%) | 88 (37) | 103 (44) |
| More than 1 extranodal site, no. (%) | 46 (19) | 42 (18) |
| Bulky disease at least 10 cm present, no. (%) | 52 (22) | 51 (21) |
| Age-adjusted IPI score,* no. (%) | ||
| Low-intermediate | 165 (69) | 145 (61) |
| High-intermediate | 69 (29) | 83 (35) |
| High | 5 (2) | 10 (4) |
No more than 65 y.