Serum asparagine deamination (depletion) at different time intervals after drug administration
| Time . | No. of patients tested . | Asparagine deamination, no. of patients (%) . |
|---|---|---|
| 2 h | 14 | 14 (100) |
| Day 7 | 16 | 16 (100) |
| Day 14 | 12 | 12 (100) |
| Days 20-21 | 11 | 9 (82) |
| Days 26-28 | 9 | 4 (44) |
| Time . | No. of patients tested . | Asparagine deamination, no. of patients (%) . |
|---|---|---|
| 2 h | 14 | 14 (100) |
| Day 7 | 16 | 16 (100) |
| Day 14 | 12 | 12 (100) |
| Days 20-21 | 11 | 9 (82) |
| Days 26-28 | 9 | 4 (44) |
Samples were obtained from 19 adult patients after a single IV dose (2000/IU/m2) of pegaspargase. Serum asparagine concentration of less than 3 μM is considered optimal deamination.44