Table 1 Inhibition of IL-12p70 by... | American Society of Hematology

Table 1

Inhibition of IL-12p70 by STA-5326

Cell type	Stimulus	Baseline value, pg/mL	IC₅₀, nM
Human PBMCs	IFN-γ/SAC	200	1
Human PBMCs	IFN-γ/LPS	180	10
Human PBMCs	SAC	5	5
Human monocytes	IFN-γ/SAC	180	1
Human dendritic cells	IFN-γ/SAC	130	5
Human THP-1	IFN-γ/SAC	60	10
Mouse PBMCs	IFN-γ/SAC	30	2
Mouse spleen cells/PBMCs	IFN-γ/SAC	250	20

Cell type	Stimulus	Baseline value, pg/mL	IC₅₀, nM
Human PBMCs	IFN-γ/SAC	200	1
Human PBMCs	IFN-γ/LPS	180	10
Human PBMCs	SAC	5	5
Human monocytes	IFN-γ/SAC	180	1
Human dendritic cells	IFN-γ/SAC	130	5
Human THP-1	IFN-γ/SAC	60	10
Mouse PBMCs	IFN-γ/SAC	30	2
Mouse spleen cells/PBMCs	IFN-γ/SAC	250	20

All IC₅₀s shown in the table are representatives of at least 3 studies.