Stereotypic IGHV1-69, IGHD3-16, and IGHJ3 rearranged antibodies
| Patient . | Reference . | HCDR3* . | LCDR3* . |
|---|---|---|---|
| CLL068 | 10 | AR(GGd)YDYvWGSYR(.sN)DAFDI | QQYGSSP(..)T |
| CLL258 | 43 | AR(GGi)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL861 | AR(GGe)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)T | |
| CLL900 | AR(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(pf)T | |
| MF9 | 10 | AR(GGp)YDYvWGSYR(.pN)DAFDI | QQYGSSP(p.)T |
| SMI | 44 | AR(GGn)YDYiWGSYR(.sN)DAFDI | QQYGSSP(p.)a |
| CLL022 | 45 | AR(GGd)YDYvWGSYR(.pN)DAFDI | |
| N_28 | 46 | AR(GGt)YDYiWGSYR(.pN)DAFDI | |
| N1659 | 47 | AR(GGd)YDYiWGSYR(.as)DAFDI | QQfnnyP(..)p |
| P896 | 47 | AR(GGp)YDYvWGSYR(.pp)DAFDI | QQYGSSl(g.)T |
| FRA-183 | 48 | AR(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(n.)T |
| ITA16903 | 48 | AR(GGn)YDYiWGSYR(.aN)DAFDI | QQYGSSP(y.)T |
| ITA16904 | 48 | AR(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| FRA-373 | 48 | AR(GGh)YDYiWGSYR(.pN)DAFDI | mQatqfP(..)l |
| FRA-204 | 48 | AR(GGi)YDYvWGSYR(.pN)DAFDI | QQYGSSP(..)l |
| FRA-331 | 48 | AR(GGh)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)s |
| CLL-A | 11 | -R(GGl)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL-B | 11 | -R(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL-C | 11 | -R(GGi)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL-D | 11 | -R(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(p.)T |
| CLL-E | 11 | -R(GGg)YDYiWGSYR(.pN)DAFDI | QQYGSSP(py)T |
| CLL-F | 11 | -R(GGl)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)s |
| CLL-G | 11 | -R(GGd)YDYiWGSYR(.sN)DAFDI | QQYGSSP(..)T |
| CLL-H | 11 | -R(GGy)YDYiWGSYR(.pN)DAFDI | QQYGSSP(pg)s |
| CLL-I | 11 | -R(GGg)YDYiWGSYR(.pN)DAFDI | QQYGnSr(i.)T |
| CLL-J | 11 | -R(GGs)YDYiWGSYR(.pN)DAFDI | QQYGSSP(pi)T |
| CLL-K | 11 | -R(GGn)YDYiWGSYR(.sN)DAFDI | QQYGSSP(sf)T |
| CLL-L | 11 | -R(GGg)YDYiWGSYR(.pN)DAFDI | QQYGSSP(l.)T |
| CLL-M | 11 | -R(GGa)YDYiWGSYR(.pp)DAFDI | QQYGSSP(l.)T |
| CLL-N | 11 | -R(GGc)YDYvWGSYR(.tN)DAFDI | QQYGSSP(ri)T |
| CLL-O | 11 | -R(GGv)YDYiWGSYR(.pN)DAFDI | QQYGSSP(..)r |
| CLL 24, Swe-131 | 49, 12 | AR(GGh)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL 26, Swe-142 | 49, 12 | AR(GGn)YDYvWGSYR(.pN)DAFDI | QQYGSSP(f.)T |
| CLL 27, Swe-208-I | 49, 12 | AR(GGy)YDYvWGSYR(.sN)DAFDI | QQYGSSP(g.)T |
| CLL 28, Swe-209-I, p239 | 49, 12, 24 | AR(GGd)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| MC67 | 50 | AR(GGn)YDYvWGSYR(.pN)DAFDI | |
| MC159 | 50 | AR(GGd)YDYiWGSYR(.pN)DAFDI | |
| MC160 | 50 | AR(GGd)YDYvWGSYR(.pN)DAFDI | |
| MC161 | 50 | AR(GGf)YDYiWGSYR(.sN)DAFDI | |
| MC162 | 50 | AR(GGg)YDYiWGSYR(.pN)DAFDI | |
| MC163 | 50 | AR(GGg)YDYiWGSYR(.sN)DAFDI | |
| MC164 | 50 | AR(GGv)YDYvWGSYR(.pN)DAFDI | |
| F156 | 12 | AR(GGy)YDYvWGSYR(.pN)DAFDI | |
| FAV-174 | 12 | AR(GGn)YDYiWGSYR(.pN)DAFDI | |
| P3810 | 12 | AR(GGy)YDYvWGSYR(.pN)DAFDI | |
| Swe-222 | 12 | AR(eG.).DYvWGSYR(yra)DAFDI | |
| Swe-434-I | 12 | AR(GGy)YDYvWGSYR(.pN)DAFDI | |
| Swe-448-I | 12 | AR(GGa)YDYiWGSYR(.sN)DAFDI | |
| ID-7 | 24 | AR(GGg)YDYvWGSYR(.pN)DAFDI | |
| Consensus | AR(GGx)YDYxWGSYR(.xN)DAFDI | QQYGSSP(x.)T | |
| Germline | 51 | AR(e.y)YDYvWGSYR(.yt)DAFDI | QQYGSSP(sx)T |
| Patient . | Reference . | HCDR3* . | LCDR3* . |
|---|---|---|---|
| CLL068 | 10 | AR(GGd)YDYvWGSYR(.sN)DAFDI | QQYGSSP(..)T |
| CLL258 | 43 | AR(GGi)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL861 | AR(GGe)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)T | |
| CLL900 | AR(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(pf)T | |
| MF9 | 10 | AR(GGp)YDYvWGSYR(.pN)DAFDI | QQYGSSP(p.)T |
| SMI | 44 | AR(GGn)YDYiWGSYR(.sN)DAFDI | QQYGSSP(p.)a |
| CLL022 | 45 | AR(GGd)YDYvWGSYR(.pN)DAFDI | |
| N_28 | 46 | AR(GGt)YDYiWGSYR(.pN)DAFDI | |
| N1659 | 47 | AR(GGd)YDYiWGSYR(.as)DAFDI | QQfnnyP(..)p |
| P896 | 47 | AR(GGp)YDYvWGSYR(.pp)DAFDI | QQYGSSl(g.)T |
| FRA-183 | 48 | AR(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(n.)T |
| ITA16903 | 48 | AR(GGn)YDYiWGSYR(.aN)DAFDI | QQYGSSP(y.)T |
| ITA16904 | 48 | AR(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| FRA-373 | 48 | AR(GGh)YDYiWGSYR(.pN)DAFDI | mQatqfP(..)l |
| FRA-204 | 48 | AR(GGi)YDYvWGSYR(.pN)DAFDI | QQYGSSP(..)l |
| FRA-331 | 48 | AR(GGh)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)s |
| CLL-A | 11 | -R(GGl)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL-B | 11 | -R(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL-C | 11 | -R(GGi)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL-D | 11 | -R(GGd)YDYvWGSYR(.pN)DAFDI | QQYGSSP(p.)T |
| CLL-E | 11 | -R(GGg)YDYiWGSYR(.pN)DAFDI | QQYGSSP(py)T |
| CLL-F | 11 | -R(GGl)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)s |
| CLL-G | 11 | -R(GGd)YDYiWGSYR(.sN)DAFDI | QQYGSSP(..)T |
| CLL-H | 11 | -R(GGy)YDYiWGSYR(.pN)DAFDI | QQYGSSP(pg)s |
| CLL-I | 11 | -R(GGg)YDYiWGSYR(.pN)DAFDI | QQYGnSr(i.)T |
| CLL-J | 11 | -R(GGs)YDYiWGSYR(.pN)DAFDI | QQYGSSP(pi)T |
| CLL-K | 11 | -R(GGn)YDYiWGSYR(.sN)DAFDI | QQYGSSP(sf)T |
| CLL-L | 11 | -R(GGg)YDYiWGSYR(.pN)DAFDI | QQYGSSP(l.)T |
| CLL-M | 11 | -R(GGa)YDYiWGSYR(.pp)DAFDI | QQYGSSP(l.)T |
| CLL-N | 11 | -R(GGc)YDYvWGSYR(.tN)DAFDI | QQYGSSP(ri)T |
| CLL-O | 11 | -R(GGv)YDYiWGSYR(.pN)DAFDI | QQYGSSP(..)r |
| CLL 24, Swe-131 | 49, 12 | AR(GGh)YDYvWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| CLL 26, Swe-142 | 49, 12 | AR(GGn)YDYvWGSYR(.pN)DAFDI | QQYGSSP(f.)T |
| CLL 27, Swe-208-I | 49, 12 | AR(GGy)YDYvWGSYR(.sN)DAFDI | QQYGSSP(g.)T |
| CLL 28, Swe-209-I, p239 | 49, 12, 24 | AR(GGd)YDYiWGSYR(.pN)DAFDI | QQYGSSP(g.)T |
| MC67 | 50 | AR(GGn)YDYvWGSYR(.pN)DAFDI | |
| MC159 | 50 | AR(GGd)YDYiWGSYR(.pN)DAFDI | |
| MC160 | 50 | AR(GGd)YDYvWGSYR(.pN)DAFDI | |
| MC161 | 50 | AR(GGf)YDYiWGSYR(.sN)DAFDI | |
| MC162 | 50 | AR(GGg)YDYiWGSYR(.pN)DAFDI | |
| MC163 | 50 | AR(GGg)YDYiWGSYR(.sN)DAFDI | |
| MC164 | 50 | AR(GGv)YDYvWGSYR(.pN)DAFDI | |
| F156 | 12 | AR(GGy)YDYvWGSYR(.pN)DAFDI | |
| FAV-174 | 12 | AR(GGn)YDYiWGSYR(.pN)DAFDI | |
| P3810 | 12 | AR(GGy)YDYvWGSYR(.pN)DAFDI | |
| Swe-222 | 12 | AR(eG.).DYvWGSYR(yra)DAFDI | |
| Swe-434-I | 12 | AR(GGy)YDYvWGSYR(.pN)DAFDI | |
| Swe-448-I | 12 | AR(GGa)YDYiWGSYR(.sN)DAFDI | |
| ID-7 | 24 | AR(GGg)YDYvWGSYR(.pN)DAFDI | |
| Consensus | AR(GGx)YDYxWGSYR(.xN)DAFDI | QQYGSSP(x.)T | |
| Germline | 51 | AR(e.y)YDYvWGSYR(.yt)DAFDI | QQYGSSP(sx)T |
Germline junctional sequences assume no N additions or nucleotide trimming with the exception of a single nucleotide deletion in the D-J or V-J junctions to maintain reading frame. Uppercase letters indicate conserved sequences; “—”, unknown sequence; “.”, gap in sequence introduced for alignment purposes.
CDR3 shown in single letter amino acid code with V-D, D-J, V-J junctional sequences enclosed by parentheses.