Outcome of asparaginase randomization
| . | E coli . | Erwinia . | P . |
|---|---|---|---|
| Total n | 147 | 139 | — |
| Any toxicity, % | 24 | 10 | <.01 |
| Allergy, % | 14 | 6 | .03 |
| Pancreatitis, % | 6 | 2 | .14 |
| Thrombosis, % | 5 | 1 | .17 |
| Relapse, % | 10 | 19 | .02 |
| Marrow only | 7 | 11 | .41 |
| CNS involved | 1 | 6 | <.01 |
| 5-y EFS, % | 89 ± 3 | 78 ± 4 | .01 |
| . | E coli . | Erwinia . | P . |
|---|---|---|---|
| Total n | 147 | 139 | — |
| Any toxicity, % | 24 | 10 | <.01 |
| Allergy, % | 14 | 6 | .03 |
| Pancreatitis, % | 6 | 2 | .14 |
| Thrombosis, % | 5 | 1 | .17 |
| Relapse, % | 10 | 19 | .02 |
| Marrow only | 7 | 11 | .41 |
| CNS involved | 1 | 6 | <.01 |
| 5-y EFS, % | 89 ± 3 | 78 ± 4 | .01 |
— indicates not applicable.