Results of Protocol 95-01 for 491 children with ALL
| . | Total . | SR . | HR* . |
|---|---|---|---|
| No. of patients | 491 | 272 | 219 |
| Percent of total | 100 | 55 | 45 |
| Induction failures | 7 | 0 | 7 |
| Induction deaths | 4 | 2 | 2 |
| Complete remissions, no. (%) | 480 (98) | 270 (99) | 210 (96) |
| Relapses, no. (%) | 78 (16) | 39 (14) | 39 (18) |
| BM only | 56 | 26 | 30 |
| CNS only | 3 | 2 | 1 |
| CNS + BM | 12 | 6 | 6 |
| Testis | 2 | 0 | 2 |
| Testis + BM | 3 | 3 | 0 |
| Other† | 2 | 2 | 0 |
| Remission deaths | 3 | 0 | 3 |
| Continuous remission | 399 | 231 | 168 |
| 5-y EFS ± SE, % | 82 ± 2 | 86 ± 2 | 76 ± 3 |
| 5-y LFS ± SE, % | 83 ± 2 | 87 ± 2 | 78 ± 3 |
| 5-y OS ± SE, % | 90 ± 1 | 95 ± 1 | 84 ± 3 |
| . | Total . | SR . | HR* . |
|---|---|---|---|
| No. of patients | 491 | 272 | 219 |
| Percent of total | 100 | 55 | 45 |
| Induction failures | 7 | 0 | 7 |
| Induction deaths | 4 | 2 | 2 |
| Complete remissions, no. (%) | 480 (98) | 270 (99) | 210 (96) |
| Relapses, no. (%) | 78 (16) | 39 (14) | 39 (18) |
| BM only | 56 | 26 | 30 |
| CNS only | 3 | 2 | 1 |
| CNS + BM | 12 | 6 | 6 |
| Testis | 2 | 0 | 2 |
| Testis + BM | 3 | 3 | 0 |
| Other† | 2 | 2 | 0 |
| Remission deaths | 3 | 0 | 3 |
| Continuous remission | 399 | 231 | 168 |
| 5-y EFS ± SE, % | 82 ± 2 | 86 ± 2 | 76 ± 3 |
| 5-y LFS ± SE, % | 83 ± 2 | 87 ± 2 | 78 ± 3 |
| 5-y OS ± SE, % | 90 ± 1 | 95 ± 1 | 84 ± 3 |