Table 2. Laboratory value associations... | American Society of Hematology

Table 2.

Laboratory value associations with LDH in sickle cell disease

Interpretation, variable	No.	r	P
Hemolysis
*Hemoglobin*	*212*	*-0.56*	*<.001*
Plasma hemoglobin	170	0.45	<.001
*Reticulocyte count*	*202*	*0.43*	*<.001*
Haptoglobin	167	-0.26	.001
*Hemoglobin S*	*212*	*0.36*	*<.001*
Arginase	119	0.35	<.001
Hemolysis plus hepatic
*AST*	*213*	*0.74*	*<.001*
Indirect bilirubin	213	0.55	<.001
*Direct bilirubin*	*213*	*0.55*	*<.001*
Hepatic
*ALT*	*213*	*0.34*	*<.001*
Hepatic plus bone
*Alkaline phosphatase*	*213*	*0.17*	*.01*
Leukocytes
*Leukocyte count*	*212*	*0.34*	*<.001*
Muscle
*Creatine kinase*	*212*	*-0.14*	*.04*
Renal
*Creatinine*	*213*	*-0.10*	.1
Endothelial activation
*Soluble VCAM-1*	*161*	*0.38*	*<.001*
Soluble ICAM-1	155	0.16	.04
*Soluble E-selectin*	*152*	*0.28*	*.001*
Soluble P-selectin	157	0.16	.04
Pulmonary
*Oxygen saturation*	*142*	*-0.44*	*<.001*

Interpretation, variable	No.	r	P
Hemolysis
*Hemoglobin*	*212*	*-0.56*	*<.001*
Plasma hemoglobin	170	0.45	<.001
*Reticulocyte count*	*202*	*0.43*	*<.001*
Haptoglobin	167	-0.26	.001
*Hemoglobin S*	*212*	*0.36*	*<.001*
Arginase	119	0.35	<.001
Hemolysis plus hepatic
*AST*	*213*	*0.74*	*<.001*
Indirect bilirubin	213	0.55	<.001
*Direct bilirubin*	*213*	*0.55*	*<.001*
Hepatic
*ALT*	*213*	*0.34*	*<.001*
Hepatic plus bone
*Alkaline phosphatase*	*213*	*0.17*	*.01*
Leukocytes
*Leukocyte count*	*212*	*0.34*	*<.001*
Muscle
*Creatine kinase*	*212*	*-0.14*	*.04*
Renal
*Creatinine*	*213*	*-0.10*	.1
Endothelial activation
*Soluble VCAM-1*	*161*	*0.38*	*<.001*
Soluble ICAM-1	155	0.16	.04
*Soluble E-selectin*	*152*	*0.28*	*.001*
Soluble P-selectin	157	0.16	.04
Pulmonary
*Oxygen saturation*	*142*	*-0.44*	*<.001*

Spearman correlation coefficients (r) and 2-tailed P values show degree of correlation of serum LDH level with various laboratory markers in a population of 213 patients with all forms of sickle cell disease.

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