Development of liver injury and pancytopenia in the [H2-Ab1−/− → C3H] mice
| Parameter . | Naive . | [WT → C3H] . | [H2-Ab1−/− → C3H] . |
|---|---|---|---|
| No. of mice | 5 | 4 | 5 |
| Liver | |||
| AST level, IU/L | 72.2 ± 11.3 | 94.3 ± 26.9 | 364.5 ± 17.7* |
| ALT level, IU/L | 27.0 ± 5.4 | 43.3 ± 15.8 | 138.0 ± 68.0* |
| ALP level, IU/L | 312.0 ± 126.0 | 446.5 ± 22.7 | 634.6 ± 132.7 |
| Bilirubin level, mg/dL | 0.08 ± 0.03 | 0.08 ± 0.01 | 0.18 ± 0.06* |
| CBCs | |||
| White blood cell count, × 109/L | 10.6 ± 3.8 | 13.0 ± 3.1 | 4.2 ± 2.3† |
| Red blood cell count, × 1012/L | 8.9 ± 0.3 | 7.9 ± 8.3 | 5.2 ± 1.6* |
| Hemoglobin level, g/L | 132.0 ± 5.0 | 129.6 ± 14.2 | 95.2 ± 15.0* |
| Platelet count, × 109/L | 731.3 ± 83.0 | 798.0 ± 17.7 | 31.4 ± 22.3† |
| Parameter . | Naive . | [WT → C3H] . | [H2-Ab1−/− → C3H] . |
|---|---|---|---|
| No. of mice | 5 | 4 | 5 |
| Liver | |||
| AST level, IU/L | 72.2 ± 11.3 | 94.3 ± 26.9 | 364.5 ± 17.7* |
| ALT level, IU/L | 27.0 ± 5.4 | 43.3 ± 15.8 | 138.0 ± 68.0* |
| ALP level, IU/L | 312.0 ± 126.0 | 446.5 ± 22.7 | 634.6 ± 132.7 |
| Bilirubin level, mg/dL | 0.08 ± 0.03 | 0.08 ± 0.01 | 0.18 ± 0.06* |
| CBCs | |||
| White blood cell count, × 109/L | 10.6 ± 3.8 | 13.0 ± 3.1 | 4.2 ± 2.3† |
| Red blood cell count, × 1012/L | 8.9 ± 0.3 | 7.9 ± 8.3 | 5.2 ± 1.6* |
| Hemoglobin level, g/L | 132.0 ± 5.0 | 129.6 ± 14.2 | 95.2 ± 15.0* |
| Platelet count, × 109/L | 731.3 ± 83.0 | 798.0 ± 17.7 | 31.4 ± 22.3† |
The complete blood counts (CBCs) and serum indices of liver damage were measured 10 weeks after BMT. The data are expressed as the mean ± SD.
To convert bilirubin level from milligrams per deciliter to micromoles per liter, multiply milligrams per deciliter by 17.1.
P < .05, [WT → C3H] versus [H2-Ab1−/− → C3H].
P < .01, [WT → C3H] versus [H2-Ab1−/− → C3H].