Table 1.

Patient characteristics prior to allo- or syn-SCT

UPN allogeneic
Diagnosis
Age at dx, y
Type of paraprotein
Dominant organ affected*
Other organs involved*
No. involved organs*
Conventional chemo
Auto-SCT/no. auto-SCTs
PS*
Time from dx to SCT, mo
Graft/donor
Non-RIC            
26256341   AL   33   Kappa   Kidney   Liver   3   VMCP   No   Good   9   BM/MRD  
23491761   AL   55   IgG lambda   Kidney   None   1   No   No   Good   3   BM/MRD  
24006981   AL   30   IgG lambda   Kidney   Liver, PNP   2   No   No   Good   63   PB/MRD  
16092762   AL   42   Kappa   None†  Gut   2   No   Yes/1   Good   44   BM/MUD  
7179454   AL/MM IIA   44   IgG kappa   Macroglossia   Skin, gut, kidney, spleen   2   C-VAMP   No   Good   9   BM/MRD  
23924891   AL/MM IA   46   Lambda   Kidney   None   1   VAD, IDM   No   Good   19   BM/MRD  
23925391   AL/MM IA   48   IgG + IgD lambda   Kidney   None   1   VAD, IDM   No   Good   9   BM/MRD  
RIC            
38906001   AL   42   IgG lambda   Kidney   Heart   2   No   No   Poor   6   PB/MRD  
25596342   AL   43   IgG lambda   Liver   Kidney, heart   3   MP, dexa   Yes/1   Good   30   PB/MRD  
1600237   AL   46   IgG lambda   Kidney   Heart, gut   3   No   Yes/1   Poor   13   PB/MRD  
81100832   AL   53   IgG lambda   Kidney   Heart   2   No   Yes/1   Poor   9   PB/MRD  
23908912   AL   54   Kappa   Muscle   None   1   VAD   Yes/1   Good   29   PB/mmRD  
1600231   AL/MMIIIB   45   Kappa   Muscle, macroglossia   Gut, kidney   3   Dexa/VAD   Yes/1   Good   10   PB/MUD  
33998213   AL/MM IA   47   IgG lambda   Kidney   None   1   VAD, MP, IFN, Thal   Yes/2   Good   122   PB/MRD  
77247721   AL/MM IA   56   Lambda   Heart   Soft tissue   2   No   No   Poor   3   PB/MRD  
Syngeneic            
23923221   AL   32   Lambda   Kidney   Heart, Liver, spleen, PNP   5   MP   No   Good   11   BM/syn  
61402181   AL   52   Lambda   PNP   Joints, gut   2   MP   No   Good   13   PB/syn  
21405051   AL   62   Lambda   PNP   Gut, heart   3   MP   No   Poor   4   PB/syn  
26203731
 		 AL
 		 29
 		 Lambda
 		 Heart‡
 		 None
 		 1
 		 No
 		 No
 		 Poor
 		 2
 		 PB/syn
 
UPN allogeneic
Diagnosis
Age at dx, y
Type of paraprotein
Dominant organ affected*
Other organs involved*
No. involved organs*
Conventional chemo
Auto-SCT/no. auto-SCTs
PS*
Time from dx to SCT, mo
Graft/donor
Non-RIC            
26256341   AL   33   Kappa   Kidney   Liver   3   VMCP   No   Good   9   BM/MRD  
23491761   AL   55   IgG lambda   Kidney   None   1   No   No   Good   3   BM/MRD  
24006981   AL   30   IgG lambda   Kidney   Liver, PNP   2   No   No   Good   63   PB/MRD  
16092762   AL   42   Kappa   None†  Gut   2   No   Yes/1   Good   44   BM/MUD  
7179454   AL/MM IIA   44   IgG kappa   Macroglossia   Skin, gut, kidney, spleen   2   C-VAMP   No   Good   9   BM/MRD  
23924891   AL/MM IA   46   Lambda   Kidney   None   1   VAD, IDM   No   Good   19   BM/MRD  
23925391   AL/MM IA   48   IgG + IgD lambda   Kidney   None   1   VAD, IDM   No   Good   9   BM/MRD  
RIC            
38906001   AL   42   IgG lambda   Kidney   Heart   2   No   No   Poor   6   PB/MRD  
25596342   AL   43   IgG lambda   Liver   Kidney, heart   3   MP, dexa   Yes/1   Good   30   PB/MRD  
1600237   AL   46   IgG lambda   Kidney   Heart, gut   3   No   Yes/1   Poor   13   PB/MRD  
81100832   AL   53   IgG lambda   Kidney   Heart   2   No   Yes/1   Poor   9   PB/MRD  
23908912   AL   54   Kappa   Muscle   None   1   VAD   Yes/1   Good   29   PB/mmRD  
1600231   AL/MMIIIB   45   Kappa   Muscle, macroglossia   Gut, kidney   3   Dexa/VAD   Yes/1   Good   10   PB/MUD  
33998213   AL/MM IA   47   IgG lambda   Kidney   None   1   VAD, MP, IFN, Thal   Yes/2   Good   122   PB/MRD  
77247721   AL/MM IA   56   Lambda   Heart   Soft tissue   2   No   No   Poor   3   PB/MRD  
Syngeneic            
23923221   AL   32   Lambda   Kidney   Heart, Liver, spleen, PNP   5   MP   No   Good   11   BM/syn  
61402181   AL   52   Lambda   PNP   Joints, gut   2   MP   No   Good   13   PB/syn  
21405051   AL   62   Lambda   PNP   Gut, heart   3   MP   No   Poor   4   PB/syn  
26203731
 		 AL
 		 29
 		 Lambda
 		 Heart‡
 		 None
 		 1
 		 No
 		 No
 		 Poor
 		 2
 		 PB/syn
 

dx indicates diagnosis; Non-RIC, non-reduced-intensity conditioning; VMCP, vincristin/melphalan/cyclophosphamide/prednisone; BM, bone marrow; MRD, matched related donor; PNP, polyneuropathy; PB, peripheral blood; MUD, matched unrelated donor; C-VAMP, cyclophosphamide/vincristine/adriamycine/melphalan/prednisone; VAD, vincristine/adriamycin/dexamethasone; IDM, intermediate-dosed melphalan; MP, melphalan/prednisone; dexa, dexamethasone; mmRD, mismatched related donor; IFN, interferon alpha; and Thal, thalidomide.

*

At allo- or syn-SCT.

†

After cardiac transplantation.

‡

After liver transplantation.

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